Sites at which mitochondria contact the endoplasmic reticulum co-localize the replication of mitochondria and their DNA to help ensure that DNA is distributed appropriately between the newly formed organelles in cells.
A Murley, LL Lackner, C Osman, M West, GK Voeltz, P Walter, J Nunnari
A protein called PVRL4 has a central role in a number of cancers that originate in epithelial tissue, and anti-PVRL4 antibodies could be used to treat some of these cancers.
NN Pavlova, C Pallasch, AE Elia, CJ Braun, TF Westbrook, M Hemann, SJ Elledge
Secretory cells in the fruit fly reproductive tract produce secretions that control ovulation through a conserved mechanism that could provide insights into ovarian cancer.
COPII vesicles regulate the metabolism of cholesterol through the selective transport of secretory proteins.
X Chen, H Wang, K Bajaj, P Zhang, Z Meng, D Ma, Y Bai, H Liu, E Adams, A Baines, G Yu, MA Sartor, B Zhang, Z Yi, J Lin, SG Young, R Schekman, D Ginsburg
A protein complex that enables cells to transport substances across their membranes, and that typically consists of four subunits, can also function as two hemicomplexes, each with two subunits.
M Gu, Q Liu, S Watanabe, L Sun, G Hollopeter, BD Grant, EM Jorgensen