Chronic and excessive inflammation can lead to exhaustion of the supply of hematopoietic stem cells and to myeloid malignancies in mice, mimicking important aspects of the myelodysplastic syndrome found in humans.
JL Zhao, DS Rao, RM O’Connell, Y Garcia-Flores, D Baltimore
Identifying and treating those groups of individuals that are most likely to transmit the malaria parasite to mosquitoes could help to control the spread of the disease.
TS Churcher, T Bousema, M Walker, C Drakeley, P Schneider, AL Ouédraogo, M Basáñez
Charybdotoxin, a toxin produced by scorpions, blocks a K+channel by binding in a lock-and-key fashion to the mouth of the channel and presenting a lysine amino group, which serves as a K+mimic in the selectivity filter.
The ability of Manduca moths to recognize changes in the profile of volatile compounds released by plants being attacked by Manduca caterpillars allows them to lay their eggs on plants that are less likely to be attacked by insects and other predators, and to avoid competing against other caterpillars of the same species for resources.
S Allmann, A Späthe, S Bisch-Knaden, M Kallenbach, A Reinecke, S Sachse, IT Baldwin, BS Hansson
The receptor EBI2 is essential for correctly positioning CD4+ dendritic cells in the spleen so that they can present blood-borne antigens to T cells and thereby provoke an antibody response.