Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics
   2. Neuroscience

   Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia

   Bohan Zhu, Richard I Ainsworth ... Javier González-Maeso

   Age and antipsychotic treatment effects on chromatin organization in the frontal cortex of schizophrenia subjects.
2. 1. Cancer Biology
   2. Genetics and Genomics

   Convergent epigenetic evolution drives relapse in acute myeloid leukemia

   Kevin Nuno, Armon Azizi ... Ravindra Majeti

   Integrated analyses of acute myeloid leukemia genetics and epigenetics demonstrate that epigenetic evolution occurs in a convergent manner in the absence of DNA mutations at relapse post-chemotherapy.
3. 1. Genetics and Genomics

   De novo variants in PLCG1 are associated with hearing impairment, ocular pathology, and cardiac defects

   Mengqi Ma, Yiming Zheng ... Hugo J. Bellen
4. 1. Genetics and Genomics

   Saccharomyces cerevisiae Rev7 regulates DSB repair pathway choice through binding and blocking Mre11 nuclease and Rad50 ATPase activities

   Sugith Badugu, Kshitiza M. Dhyani ... Kalappa Muniyappa
5. 1. Genetics and Genomics

   Mono-methylated histones control PARP-1 in chromatin and transcription

   Gbolahan Bamgbose, Guillaume Bordet ... Alexei Tulin
6. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Haplotype function score improves biological interpretation and cross-ancestry polygenic prediction of human complex traits

   Weichen Song, Yongyong Shi, Guan Ning Lin

   Using sequence-determined functional genomic features instead of original genotypes can partially overcome challenges in genetic association studies, such as rare variant exclusion and population structure.
7. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Transposable elements regulate thymus development and function

   Jean-David Larouche, Céline M Laumont ... Claude Perreault

   Multiomic analyses provide new insights into the involvement of transposable elements in T-cell development in the thymus and central tolerance induction.
8. 1. Developmental Biology
   2. Genetics and Genomics

   ARID1A governs the silencing of sex-linked transcription during male meiosis in the mouse

   Debashish U. Menon, Prabuddha Chakraborty ... Terry Magnuson
9. 1. Genetics and Genomics

   Explaining the counter-intuitive effectiveness of trophectoderm biopsy for PGT-A using computational modelling

   Benjamin M Skinner, Manuel Viotti ... Peter JI Ellis
10. 1. Genetics and Genomics

    Defective CAPSL function causes impaired retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy

    Wenjing Liu, Shujin Li ... Xianjun Zhu