Medicine

Latest articles

1. 1. Medicine
   2. Neuroscience

   Ketamine induces multiple individually distinct whole-brain functional connectivity signatures

   Flora Moujaes, Jie Lisa Ji ... Alan Anticevic

   There is substantial individual variation in behavioral and neural responses to acute ketamine administration in healthy controls, which emphasises the need for personalized approaches when harnessing ketamine as a treatment for depression.
2. 1. Medicine

   The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

   Arya Y. Nakhe, Prasanna K. Dadi ... David A. Jacobson
3. 1. Medicine

   Hammerhead-type FXR agonists induce an enhancer RNA Fincor that ameliorates nonalcoholic steatohepatitis in mice

   Jinjing Chen, Ruoyu Wang ... Jongsook Kemper

   Pharmacological activation of farnesoid X (FXR) receptor by hammerhead-type agonists induces a novel enhancer RNA, termed Fincor, contributing to the amelioration of nonalcoholic steatohepatitis in mice.
4. 1. Cell Biology
   2. Medicine

   Chemotherapy activates inflammasomes to cause inflammation-associated bone loss

   Chun Wang, Khushpreet Kaur ... Gabriel Mbalaviele

   Inflammasome-mediated inflammation is critically involved in bone loss caused by doxorubicin.
5. 1. Medicine

   Senescence of endplate osteoclasts induces sensory innervation and spinal pain

   Dayu Pan, Kheiria Gamal Benkato ... Xu Cao
6. 1. Biochemistry and Chemical Biology
   2. Medicine

   Bone canonical Wnt signaling is downregulated in type 2 diabetes and associates with higher advanced glycation end-products (AGEs) content and reduced bone strength

   Giulia Leanza, Francesca Cannata ... Nicola Napoli

   In individuals with type 2 diabetes, downregulation of bone canonical Wnt signaling is linked to higher levels of advanced glycation end-products within the bone, contributing to lower bone strength.
7. 1. Medicine

   Current perspectives on the multiple roles of osteoclasts: Mechanisms of osteoclast–osteoblast communication and potential clinical implications

   Valentina Daponte, Katrin Henke, Hicham Drissi

   A comprehensive review focusing on the role of osteoclasts as active regulators of bone homeostasis by influencing osteoblast function explores the currently known mechanisms and coupling factors involved in osteoclast–osteoblast communication and their potential as treatments for bone diseases.
8. 1. Medicine

   Identification of Novel Syncytiotrophoblast Membrane Extracellular Vesicles Derived Protein Biomarkers in Early-onset Preeclampsia: A Cross-Sectional Study

   Toluwalase Awoyemi, Shuhan Jiang ... Manu Vatish
9. 1. Medicine

   Serum proteomic profiling of physical activity reveals CD300LG as a novel exerkine with a potential causal link to glucose homeostasis

   Sindre Lee-Ødegård, Marit Hjorth ... Kåre I. Birkeland
10. 1. Medicine

    Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population based cohort study

    Ruijie Zeng, Yuying Ma ... Hao Chen