Medicine

Latest articles

1. 1. Medicine

   Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner

   Anika Shimonty, Fabrizio Pin ... Lynda F Bonewald

   Analysis of mice lacking the precursor for irisin, FNDC5, provides evidence for a sex-specific role of irisin in calcium release from bone due to osteocytic osteolysis.
2. 1. Medicine
   2. Microbiology and Infectious Disease

   Altered transcriptomic immune responses of maintenance hemodialysis patients to the COVID-19 mRNA vaccine

   Yi-Shin Chang, Kai Huang ... David L Perkins

   Differing time courses of immune responses to the BTN162b2 mRNA COVID-19 vaccination in maintenance hemodialysis subjects are comparable to healthy controls and identify transcriptomic and clinical predictors of anti-spike IgG titers in hemodialysis subjects.
3. 1. Medicine

   Relationship between circulating FSH levels and body composition and bone health in patients with prostate cancer who undergo androgen deprivation therapy: The BLADE study

   Marco Bergamini, Alberto Dalla Volta ... Alfredo Berruti

   Follicle-stimulating hormone in the reference range influences body composition in men exposed to hormone-deprivation therapy for prostate cancer.
4. 1. Medicine

   Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury

   Venkateshwari Varadharajan, Iyappan Ramachandiran ... J Mark Brown

   MBOAT7 loss of function in hepatocytes contributes to ethanol-induced liver injury, offering crucial insights into the dysregulated lipid metabolism and impaired autophagy associated with advanced liver disease.
5. 1. Medicine
   2. Cancer Biology

   RGS10 deficiency facilitates distant metastasis by inducing epithelial–mesenchymal transition in breast cancer

   Yang Liu, Yi Jiang ... Xi Gu
6. 1. Medicine
   2. Neuroscience

   Ketamine induces multiple individually distinct whole-brain functional connectivity signatures

   Flora Moujaes, Jie Lisa Ji ... Alan Anticevic

   There is substantial individual variation in behavioral and neural responses to acute ketamine administration in healthy controls, which emphasises the need for personalized approaches when harnessing ketamine as a treatment for depression.
7. 1. Medicine

   The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

   Arya Y. Nakhe, Prasanna K. Dadi ... David A. Jacobson
8. 1. Medicine

   Hammerhead-type FXR agonists induce an enhancer RNA Fincor that ameliorates nonalcoholic steatohepatitis in mice

   Jinjing Chen, Ruoyu Wang ... Jongsook Kemper

   Pharmacological activation of farnesoid X (FXR) receptor by hammerhead-type agonists induces a novel enhancer RNA, termed Fincor, contributing to the amelioration of nonalcoholic steatohepatitis in mice.
9. 1. Cell Biology
   2. Medicine

   Chemotherapy activates inflammasomes to cause inflammation-associated bone loss

   Chun Wang, Khushpreet Kaur ... Gabriel Mbalaviele

   Inflammasome-mediated inflammation is critically involved in bone loss caused by doxorubicin.
10. 1. Medicine

    Senescence of endplate osteoclasts induces sensory innervation and spinal pain

    Dayu Pan, Kheiria Gamal Benkato ... Xu Cao