Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Seemingly disparate working memory biases, including short-term serial and contraction biases, may arise from a common mechanism via the interaction of multiple networks, each operating over a distinct timescale.
Subtelomeric sequences in the yeast S. cerevisiae are dispensable for either cell proliferation or homologous recombination-mediated telomere maintenance in telomerase-null cells, suggesting that these sequences represent remnants of genome evolution.
Structural promiscuity in PURA protein, induced by patient mutations, impacts nucleic acid binding, unwinding, and subcellular localization, indicating why so many patients display the full disease spectrum of PURA syndrome.
Foxp3 and Ikaros, two transcription factors genetically linked to autoimmune disease in humans, cooperate to establish the epigenomic and transcriptomic landscape of regulatory T cells.
Intense starvation with high internal energy levels results in remarkably stable food-related memories that persist beyond actual food intake and are associated with overeating.
Alexander D Cook, Mark Carrington, Matthew K Higgins
A structure derived from cryogenic electron microscopy shows how ISG65, an African trypanosome receptor that aids virulence, binds C3b and suggests mechanisms through which ISG65 might aid complement resistance.
The mechanical stability of a nucleosome is enhanced upon the introduction of a single base pair mismatch that makes DNA more bendable, with implications on mismatch repair in vivo.
Differing time courses of immune responses to the BTN162b2 mRNA COVID-19 vaccination in maintenance hemodialysis subjects are comparable to healthy controls and identify transcriptomic and clinical predictors of anti-spike IgG titers in hemodialysis subjects.
An unbiased approach unveils a non-canonical substrate of the known transporters, highlighting the mechanism behind the use of D-serine as a kidney biomarker.
