Figure 1—figure supplement 7. | Passive and active DNA methylation and the interplay with genetic variation in gene regulation

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Passive and active DNA methylation and the interplay with genetic variation in gene regulation

Figure 1—figure supplement 7.

Affiliation details

University of Geneva Medical School, Switzerland; Institute of Genetics and Genomics in Geneva, Switzerland; Swiss Institute of Bioinformatics, Switzerland; Stanford University, United States
Figure 1—figure supplement 7.
Download figureOpen in new tabFigure 1—figure supplement 7. β-value distributions in distinct genomic features for expressed and non-expressed genes.

(A) Median β-value across individuals is plotted for CpG sites by their position relative to the nearest transcription start site (TSS) in each cell-type, for expressed (blue) and non-expressed (red) genes. Based on the region where expressed genes have lower methylation levels than non-expressed genes, the promoter proximal region of our analyses was defined from -1kb to +2kb relative to the TSS. (B)–(D) β-value distributions in genes (B), 1kb window upstream of TSS (C) and open-chromatin (D) in one LCL sample for expressed (blue) and non-expressed (red) genes. Other cell-types look very similar.

DOI: http://dx.doi.org/10.7554/eLife.00523.010