Figure 2—figure supplement 1. | Passive and active DNA methylation and the interplay with genetic variation in gene regulation

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Passive and active DNA methylation and the interplay with genetic variation in gene regulation

Figure 2—figure supplement 1.

Affiliation details

University of Geneva Medical School, Switzerland; Institute of Genetics and Genomics in Geneva, Switzerland; Swiss Institute of Bioinformatics, Switzerland; Stanford University, United States
Figure 2—figure supplement 1.
Download figureOpen in new tabFigure 2—figure supplement 1. Correlation between promoter DNA methylation and across gene expression.

(A) Shown is the median methylation level across all sites falling in the promoter region of a gene (x-axis) by the gene expression level of the gene (y-axis) as the log2 of the median number of reads per kilobase per million reads (RPKM). The background scatter plot represents the data of a single individual, while the fitted lines depict the smoothened mean distribution of values for each individual. Non-expressed genes were artificially plotted at the bottom of the plot. (B) Histogram of Spearman rank correlation coefficients for each sample of correlations explained in (A). All p values<2.2×10−16. (C) Distribution of Spearman rank correlation coefficients for each sample of correlations explained in (A) taking only expressed genes, which were used in our eQTM analyses (at least 1 exonic read in >90% of individuals). In fibroblasts (F) all p values<6.2×10−8, in LCLs (L) all p values<8.2×10−18, in T-cells (T) all p-values<2.6×10−44.

DOI: http://dx.doi.org/10.7554/eLife.00523.014