Figure 2—figure supplement 3. | Passive and active DNA methylation and the interplay with genetic variation in gene regulation

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Passive and active DNA methylation and the interplay with genetic variation in gene regulation

Figure 2—figure supplement 3.

Affiliation details

University of Geneva Medical School, Switzerland; Institute of Genetics and Genomics in Geneva, Switzerland; Swiss Institute of Bioinformatics, Switzerland; Stanford University, United States
Figure 2—figure supplement 3.
Download figureOpen in new tabFigure 2—figure supplement 3. Tissue-specific methylation is enriched with eQTMs and mQTLs.

(A) Distribution of the level of differentiation metric which we defined as the coefficient of variation of the median methylation level per cell-type for each site (i.e., standard deviation of the medians divided by the mean of medians). (B) eQTM sites have higher levels of differentiation than non-eQTM sites (C) mQTL sites have higher levels of differentiation than non-mQTL sites. Stars between box plots indicate that the difference is significant with p<2.2×10−16, Wilcoxon test. eQTM and mQTL median methylation levels cover a wide range of β-values, so removing the 113 sites that were below the minimum or above the maximum median (representing effectively unmethylated or fully methylated sites) in all three cell-types did not alter the results at all.

DOI: http://dx.doi.org/10.7554/eLife.00523.016