Figure 1—figure supplement 2. | Expanding the olfactory code by in silico decoding of odor-receptor chemical space

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Expanding the olfactory code by in silico decoding of odor-receptor chemical space

Figure 1—figure supplement 2.

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University of California, Riverside, United States
Figure 1—figure supplement 2.
Download figureOpen in new tabFigure 1—figure supplement 2. Pharmacophores of active compounds for individual Ors.

Hierarchical cluster identical to Figure 1D. Known odorant activity scale is indicated using independent color gradient scales. Horizontal black bars underneath cluster indicate part of active cluster, a subset of which were used to generate pharmacophores using the Ligand Scout program (shown underneath each Or in two orientations). Yellow = hydrophobic region, red = Hydrogen-bond acceptor, green/red = Hydrogen-bond donor or acceptor depending upon pH.

DOI: http://dx.doi.org/10.7554/eLife.01120.005