Figure 2. | Expanding the olfactory code by in silico decoding of odor-receptor chemical space

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Expanding the olfactory code by in silico decoding of odor-receptor chemical space

Figure 2.

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University of California, Riverside, United States
Figure 2.
Download figureOpen in new tabFigure 2. Electrophysiology validates that odorant receptor-optimized molecular descriptors can successfully identify new ligands for Drosophila.

Mean increase in response of neurons to 0.5-s stimulus of indicated odors (10−2 dilution) predicted for each associated Or. Dashed lines indicate the activator threshold (50 spikes/s). ΔH: Or85b (ab3B) = flies lack expression of Or22a in neighboring neuron, thus all observed neuron activation is unambiguously caused by Or85b. N = 3, error bars = s.e.m.

DOI: http://dx.doi.org/10.7554/eLife.01120.008