Figure 4. | Expanding the olfactory code by in silico decoding of odor-receptor chemical space

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Expanding the olfactory code by in silico decoding of odor-receptor chemical space

Figure 4.

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University of California, Riverside, United States
Figure 4.
Download figureOpen in new tabFigure 4. Analysis of receptor–odor relationships and breadth of tuning.

(A) Hierarchical clusters created from Euclidean distance values between Drosophila Ors calculated using: (left to right) shared optimized descriptors; known activity to training set odors (Hallem and Carlson, 2006); overlap across top 500 predicted ligands; and Phylogenic tree of receptors (Hallem and Carlson, 2006). Sub clusters shaded with colors or bars. (B) Frequency distribution of compounds from the >240K library within the top 15% distance from highest active plotted to generate predicted breadth of tuning curves. Green arrows indicate relative distance of the furthest known activating compound determined by electrophysiology.

DOI: http://dx.doi.org/10.7554/eLife.01120.010