Figure 6. | Expanding the olfactory code by in silico decoding of odor-receptor chemical space

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Expanding the olfactory code by in silico decoding of odor-receptor chemical space

Figure 6.

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University of California, Riverside, United States
Figure 6.
Download figureOpen in new tabFigure 6. Predicted odor space and network view of odor coding.

(A) Expansion of the peripheral olfactory code in this study: large increase in numbers of identified activators and inhibitors. The different sized circles represent the approximate ratio of numbers of previously known ligands (top circles), predicted ligands based on a cutoff of the top 500 predicted compounds per receptor and corrected to the validation success rate (lower, diffuse circles). (B) Drosophila receptor–odor network. Each known interaction (>50 spikes/s) from this and previous studies (Hallem and Carlson, 2006) is linked by a purple edge. Predicted receptor–odor network (top 500 hits) are linked by light-grey edges. All compounds are represented as small black circles and Ors are represented as large colored circles matching the colors used in (Figure 4A).

DOI: http://dx.doi.org/10.7554/eLife.01120.012