10,727 results found
    1. Plant Biology

    Arabidopsis 14-3-3 epsilon members contribute to polarity of PIN auxin carrier and auxin transport-related development

    Jutta Keicher, Nina Jaspert ... Claudia Oecking
    Conditional genetic inactivation of a highly conserved, ancestral subgroup of 14-3-3 proteins in Arabidopsis thaliana reveals fundamental roles in auxin transport-dependent plant development and post-Golgi trafficking processes.
    1. Plant Biology

    Shade-induced nuclear localization of PIF7 is regulated by phosphorylation and 14-3-3 proteins in Arabidopsis

    Xu Huang, Qian Zhang ... Lin Li
    A phosphorylation dependent translocation of PIF7 and involvement of 14-3-3 proteins reveal novel regulation mechanisms in shade signal transduction.
    1. Immunology and Inflammation

    IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay

    Kotaro Akaki, Kosuke Ogata ... Osamu Takeuchi
    Regnase-1, an RNase suppressing proinflammatory mRNAs, interacts with 14-3-3, which diminishes cytokine mRNA recognition and the nuclear-cytoplasmic shuttling of Regnase-1 under inflammatory conditions.
    1. Neuroscience

    14-3-3 protein augments the protein stability of phosphorylated spastin and promotes the recovery of spinal cord injury through its agonist intervention

    Qiuling Liu, Hua Yang ... Zhisheng Ji
    14-3-3 protein augments the protein stability of phosphorylated spastin and promotes the recovery of spinal cord injury in mice.
    1. Cell Biology

    Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1

    Yajuan Guo, Catherine J Redmond ... Pierre A Coulombe
    Keratin filaments are revealed as novel regulators of entry into terminal differentiation in the epidermis via an ability to modulate YAP1 function and Hippo signaling.
    1. Cell Biology

    Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5

    Illyce Nuñez, Marbelys Rodriguez Pino ... Fulvia Verde
    NDR kinase Orb6 prevents RNP granule assembly and translational repression by promoting Sts5 association with 14-3-3 protein Rad24 to spatially control polarized cell growth.
    1. Microbiology and Infectious Disease

    Legionella pneumophila regulates host cell motility by targeting Phldb2 with a 14-3-3ζ-dependent protease effector

    Lei Song, Jingjing Luo ... Zhao-Qing Luo
    A novel bacterial protease activated by a eukaryote-specific factor attacks a host protein involved in cytoskeleton organization to inhibit cell migration during Legionella pneumophila infection.
    1. Cell Biology
    2. Genetics and Genomics

    NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling

    Malini Rajan, Cole P Anderson ... Elizabeth A Leibold
    Nuclear receptor NHR-14 regulates the subcellular localization of the zinc transcription factor PQM-1 to coordinate innate immunity with iron sequestration during pathogen infection in C. elegans..
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    A back-door insight into the modulation of Src kinase activity by the polyamine spermidine

    Sofia Rossini, Marco Gargaro ... Giada Mondanelli
    A road to modulators of the kinase activity and the non-enzymatic functions of Src and IDO1 at once.
    1. Neuroscience

    Scn1a-GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons

    Tetsushi Yamagata, Ikuo Ogiwara ... Kazuhiro Yamakawa
    In neocortex, Nav1.1 is expressed in neocortical pyramidal tract projection neurons and a minor subpopulation of cortico-cortical projection neurons in addition to its predominant expression in inhibitory neurons, while the majority of cortico-thalamic, cortico-striatal, and cortico-cortical neurons express Nav1.2.

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