Francesco A Servello, Rute Fernandes ... Javier Apfeld
C. elegans nematodes can assess faithfully the threat that H2O2 poses by coupling the induction of their H2O2 defenses to the perception of high temperature—an inherent enhancer of the reactivity of H2O2.
Nathan Cermak, Stephanie K Yu ... Steven W Flavell
Simultaneous quantification of each of the main motor programs in the roundworm C. elegans yields new insights into the neural mechanisms that coordinate animal behavior.
Quantitative FRET imaging in moving C. elegans shows that stretch-unfolding of twitchin kinase occurs in the active muscle, whereby mechanical activity titrates the signaling pathway of this cytoskeletal kinase.
William M Roberts, Steven B Augustine ... Shawn R Lockery
A stochastic model of locomotory control in C. elegans based on an extensive new set of tracking data can explain and predict effects of ablations and mutations on behavior.
Malini Rajan, Cole P Anderson ... Elizabeth A Leibold
Nuclear receptor NHR-14 regulates the subcellular localization of the zinc transcription factor PQM-1 to coordinate innate immunity with iron sequestration during pathogen infection in C. elegans..
A genetic oscillator composed of NHR-23 and let-7 family of microRNAs links the molting cycle timer and the heterochronic pathway to regulate the pace of molting in C. elegans and ensure that worms molt only four times.
Cihan Erkut, Vamshidhar R Gade ... Teymuras V Kurzchalia
Roundworms and yeast can survive extreme desiccation only by switching their metabolism into a gluconeogenic mode and producing very high amounts of trehalose via the glyoxylate shunt.
Yuki Tanimoto, Akiko Yamazoe-Umemoto ... Koutarou D Kimura
A series of quantitative behavioural and opto-physiological analyses using a novel robot microscope system reveals that C. elegans computes the time-differential and time-integral of sensory information for decision-making during olfactory navigation.
Ursula Kwong-Brown, Martha L Tobias ... Darcy B Kelley
When ancestral Xenopus returned to water ~170mya, they evolved a new method for producing courtship calls underwater without airflow, using vibrations that also preserve essential acoustic information on species identity.
The transcriptomes of individual cells of the 1- to 102-cell stages in Caenorhabditis elegans embryogenesis are identified along with 119 embryonic cell states during cell fate specification, including ‘equivalence-group’ cell identities.