366 results found
    1. Computational and Systems Biology
    2. Developmental Biology

    Dynamic fibronectin assembly and remodeling by leader neural crest cells prevents jamming in collective cell migration

    William Duncan Martinson, Rebecca McLennan ... Philip K Maini
    Data-driven mathematical modeling suggests that leading neural crest cells in a moving stream can robustly communicate with trailing cells by remodeling their extracellular matrix, thereby enabling long-distance collective migration.
    1. Cell Biology
    2. Developmental Biology

    Fat2 polarizes the WAVE complex in trans to align cell protrusions for collective migration

    Audrey Miller Williams, Seth Donoughe ... Sally Horne-Badovinac
    Fat2 signals from the trailing edge of each cell to localize WAVE activity to the leading edge of the cell behind, polarizing protrusive regions within cells and across the epithelium.
    1. Cell Biology
    2. Developmental Biology

    Protein phosphatase 1 activity controls a balance between collective and single cell modes of migration

    Yujun Chen, Nirupama Kotian ... Jocelyn A McDonald
    Protein phosphatase 1 activity promotes cohesive collective cell migration by restricting actomyosin contractility to the periphery of the collective and maintaining proper cadherin–catenin complex protein levels at cell–cell junctions.
    1. Cell Biology
    2. Developmental Biology

    Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration

    Joana R Carvalho, Isabela C Fortunato ... Claudio A Franco
    Analysis of axial polarity distributions shows that Wnt5a regulates collective cell migration in vivo by stabilizing vinculin at adherens junctions and fine-tuning mechanocoupling between neighbouring cells.
    1. Developmental Biology

    The Glide/Gcm fate determinant controls initiation of collective cell migration by regulating Frazzled

    Tripti Gupta, Arun Kumar ... Angela Giangrande
    The role of the Frazzled chemoattractant receptor is to triggers migration initiation as part of the glial developmental program induced by the Glide/Gcm transcription factor.
    1. Developmental Biology

    Notch controls the cell cycle to define leader versus follower identities during collective cell migration

    Zain Alhashem, Dylan Feldner-Busztin ... Claudia Linker
    Computational modelling and experimental manipulation show that Notch signalling regulates collective cell migration by allocating distinct migratory identities through the control of cell cycle progression.
    1. Cell Biology
    2. Physics of Living Systems

    Bridging the gap between single-cell migration and collective dynamics

    Florian Thüroff, Andriy Goychuk ... Erwin Frey
    A computational model, based on single-cell features like contractility and polarizability, quantitatively describes cellular dynamics from the single cell level up to small cohorts and confluent tissues.
    1. Computational and Systems Biology
    2. Developmental Biology

    Supracellular organization confers directionality and mechanical potency to migrating pairs of cardiopharyngeal progenitor cells

    Yelena Y Bernadskaya, Haicen Yue ... Alex Mogilner
    The migrating pair of cardiac progenitors in the chordate Ciona robusta is the simplest possible supracellular cell collective whose organization helps them overcome resistance from surrounding embryonic tissues during cell migration.
    1. Cell Biology
    2. Developmental Biology

    Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration

    Lu Wei, Amir Al Oustah ... Myriam Roussigné
    Notch signaling controls the collective migration of parapineal cells through its capacity to restrict FGF pathway activation to a few leading cells.
    1. Physics of Living Systems

    Polar pattern formation induced by contact following locomotion in a multicellular system

    Masayuki Hayakawa, Tetsuya Hiraiwa ... Tatsuo Shibata
    Transient cell-cell contact of eukaryotic cells, called contact following locomotion, causes cell density segregation, and its high-density region traveled as a band within the disordered background.

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