William Duncan Martinson, Rebecca McLennan ... Philip K Maini
Data-driven mathematical modeling suggests that leading neural crest cells in a moving stream can robustly communicate with trailing cells by remodeling their extracellular matrix, thereby enabling long-distance collective migration.
Audrey Miller Williams, Seth Donoughe ... Sally Horne-Badovinac
Fat2 signals from the trailing edge of each cell to localize WAVE activity to the leading edge of the cell behind, polarizing protrusive regions within cells and across the epithelium.
Yujun Chen, Nirupama Kotian ... Jocelyn A McDonald
Protein phosphatase 1 activity promotes cohesive collective cell migration by restricting actomyosin contractility to the periphery of the collective and maintaining proper cadherin–catenin complex protein levels at cell–cell junctions.
Joana R Carvalho, Isabela C Fortunato ... Claudio A Franco
Analysis of axial polarity distributions shows that Wnt5a regulates collective cell migration in vivo by stabilizing vinculin at adherens junctions and fine-tuning mechanocoupling between neighbouring cells.
The role of the Frazzled chemoattractant receptor is to triggers migration initiation as part of the glial developmental program induced by the Glide/Gcm transcription factor.
Computational modelling and experimental manipulation show that Notch signalling regulates collective cell migration by allocating distinct migratory identities through the control of cell cycle progression.
A computational model, based on single-cell features like contractility and polarizability, quantitatively describes cellular dynamics from the single cell level up to small cohorts and confluent tissues.
Yelena Y Bernadskaya, Haicen Yue ... Alex Mogilner
The migrating pair of cardiac progenitors in the chordate Ciona robusta is the simplest possible supracellular cell collective whose organization helps them overcome resistance from surrounding embryonic tissues during cell migration.
Transient cell-cell contact of eukaryotic cells, called contact following locomotion, causes cell density segregation, and its high-density region traveled as a band within the disordered background.