309 results found
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Cell Signaling: Extraordinary effects of unnatural pairings

    Alejandro Villarino, John J O'Shea
    Engineered molecules based on human cytokines have potential uses in research and medicine.
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    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

    Ignacio Moraga, Jamie B Spangler ... K Christopher Garcia
    Synthetic cytokines engage new signaling programs with therapeutic potential.
    1. Medicine
    2. Epidemiology and Global Health

    A systematic assessment of preclinical multilaboratory studies and a comparison to single laboratory studies

    Victoria T Hunniford, Agnes Grudniewicz ... Manoj M Lalu
    Preclinical multilaboratory studies are a robust method to assess promising interventions.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    De novo-designed transmembrane domains tune engineered receptor functions

    Assaf Elazar, Nicholas J Chandler ... Sarel J Fleishman
    Designer transmembrane peptides precisely control chimeric antigen receptor signaling strength and are insulated from undesired interactions with endogenous receptors.
    1. Immunology and Inflammation

    Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

    Jonathan Martinez-Fabregas, Stephan Wilmes ... Ignacio Moraga
    Engineering cytokines to exhibit different receptor binding dwell times is a useful strategy to decouple their functional pleiotropy and reduce their toxicity in the clinic.
    1. Neuroscience

    IL-37 expression reduces acute and chronic neuroinflammation and rescues cognitive impairment in an Alzheimer’s disease mouse model

    Niklas Lonnemann, Shirin Hosseini ... Martin Korte
    Expression of an interleukin that is immune suppressive (IL-37) in mice is able to limit inflammation in the brain after acute inflammatory events and prevent loss of cognitive abilities in a mouse model of AD.
    1. Cancer Biology
    2. Medicine

    Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

    S Jordan Kerns, Chaitra Belgur ... Lauriane Cabon
    Novel human models of the lung and intestine are described and validated as preclinical in vitro tools for predictive profiling of T-cell-bispecific antibodies with expected on-target off-tumor risk.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity

    Nathella Pavan Kumar, Kiyoshi F Fukutani ... Hardy Kornfeld
    Systemic inflammation is greater in individuals with concurrent TB and diabetes than in euglycemic individuals with TB, and this disparity persists through the full 6-month course of anti-tubercular treatment.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Integration of IL-2 and IL-4 signals coordinates divergent regulatory T cell responses and drives therapeutic efficacy

    Julie Y Zhou, Carlos A Alvarez, Brian A Cobb
    Simultaneous cytokine signaling results in unexpected transcription factor changes that fuel a cellular response divergent from the sum of each cytokine alone.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Complement and CD4+ T cells drive context-specific corneal sensory neuropathy

    Derek J Royer, Jose Echegaray-Mendez ... Daniel JJ Carr
    The complement pathway can contribute to corneal sensation loss and nerve damage during ocular surface inflammation.

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