654 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Ndc80 complex bridges two Dam1 complex rings

    Jae ook Kim, Alex Zelter ... Trisha N Davis
    The ability of the Ndc80 complex to bind two Dam1 complex rings is important for chromosome attachment, and the distance between the two rings is vital for supporting growth.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    DDM1 and Lsh remodelers allow methylation of DNA wrapped in nucleosomes

    David B Lyons, Daniel Zilberman
    Nucleosomes and linker histones block eukaryotic cytosine methylation.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Mechanism of environmentally driven conformational changes that modulate H-NS DNA-bridging activity

    Ramon A van der Valk, Jocelyne Vreede ... Remus T Dame
    The DNA-bridging efficiency of H-NS, a genome organising and transcription regulatory protein, is modulated by changes in environmental conditions of the cell, which drive a structural rearrangement of the protein.
    1. Plant Biology

    UBP12 and UBP13 negatively regulate the activity of the ubiquitin-dependent peptidases DA1, DAR1 and DAR2

    Hannes Vanhaeren, Ying Chen ... Dirk Inzé
    By inactivating DA1, DAR1 and DAR2 through deubiquitination, UBP12 and UBP13 regulate leaf growth, cell area and endoreduplication.
    1. Genetics and Genomics

    Histone variants shape chromatin states in Arabidopsis

    Bhagyshree Jamge, Zdravko J Lorković ... Frédéric Berger
    In the model plant Arabidopsis thaliana genome dynamic exchanges of histone variants control the organization of histone modifications into chromatin states, acting as molecular landmarks.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Histone H1 prevents non-CG methylation-mediated small RNA biogenesis in Arabidopsis heterochromatin

    Jaemyung Choi, David B Lyons, Daniel Zilberman
    Linker histone H1 and cytosine DNA methylation in contexts other than CG explain patterns of 24 nucleotide small RNA biogenesis in Arabidopsis thaliana.
    1. Immunology and Inflammation

    LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

    Jack P Green, Tessa Swanton ... David Brough
    Depletion of LRRC8A provides genetic evidence for the importance of Cl- channels in NLRP3 activation.
    1. Microbiology and Infectious Disease

    Revisiting the guidelines for ending isolation for COVID-19 patients

    Yong Dam Jeong, Keisuke Ejima ... Marco Ajelli
    Compared with the approach isolating COVID-19 patients for a fixed period, the approach using repeated PCR testing mitigates unnecessarily lengthy isolation of patients while minimizing the risk of further transmission.
    1. Neuroscience

    Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression

    Mattia Privitera, Lukas M von Ziegler ... Johannes Bohacek
    Targeted manipulation of the locus coeruleus noradrenaline circuitry combined with extensive transcriptomic analyses in the mouse hippocampus reveal a unique set of noradrenaline-dependent, stress-related genes and point to astrocytic engagement.
    1. Neuroscience

    Freezing suppression by oxytocin in central amygdala allows alternate defensive behaviours and mother-pup interactions

    Elizabeth Rickenbacher, Rosemarie E Perry ... Marta A Moita
    Oxytocin in the amygdala suppresses freezing of mothers when exposed to a threat in the presence of their offspring, allowing for pup protection and transmission of information about danger from mothers to pups.

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