1,550 results found
    1. Developmental Biology
    2. Plant Biology

    Epigenetic reprogramming rewires transcription during the alternation of generations in Arabidopsis

    Michael Borg, Ranjith K Papareddy ... Frédéric Berger
    Epigenetic reprogramming of the distinct repressive marks H3K27me3 or H3K9me2 guides the transition between the haploid and diploid life forms that encompass the life cycle of land plants.
    1. Genetics and Genomics

    Epigenetic profiling of growth plate chondrocytes sheds insight into regulatory genetic variation influencing height

    Michael Guo, Zun Liu ... Terence D Capellini
    Epigenetic profiling of femoral growth plate chondrocytes helps whittle-down GWAS height variants to fewer putative functional variants.
    1. Genetics and Genomics

    Pervasive epigenetic effects of Drosophila euchromatic transposable elements impact their evolution

    Yuh Chwen G Lee, Gary H Karpen
    The ability of transposable elements to epigenetically influence adjacent genes impacts genome evolution by driving substantial variation in transposon numbers between species.
    1. Evolutionary Biology
    2. Genetics and Genomics

    High social status males experience accelerated epigenetic aging in wild baboons

    Jordan A Anderson, Rachel A Johnston ... Jenny Tung
    Among the factors that predict fitness in wild baboons, dominance rank in males, but not in females, is the best predictor of epigenetic aging.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates

    Hannah K Long, David Sims ... Robert J Klose
    Islands of non-methylated DNA are shown to perform a similar epigenetic role in many different vertebrate species.
    1. Cancer Biology
    2. Medicine

    Improving drug discovery using image-based multiparametric analysis of the epigenetic landscape

    Chen Farhy, Santosh Hariharan ... Alexey V Terskikh
    A novel phenotypic screening platform based on immunofluorescent imaging of histone modifications enables accurate identification of cell fates and environmental perturbations.
    1. Genetics and Genomics
    2. Neuroscience

    Epigenomic landscapes of retinal rods and cones

    Alisa Mo, Chongyuan Luo ... Jeremy Nathans
    Genome-wide analysis of DNA methylation and accessible chromatin shows that retinal rods and cones have distinct epigenomic features that reflect differences in their development and function.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock

    Maria Azkanaz, Aida Rodríguez López ... Vincent van den Boom
    Heat shock induces relocalization of epigenetic modifiers to the nucleolus, which acts as a dedicated protein quality control center that is indispensable for recovery of epigenetic regulators and epigenetic modifications.
    1. Developmental Biology
    2. Genetics and Genomics

    Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci

    Victoria J Sugrue, Joseph Alan Zoller ... Steve Horvath
    Epigenetic clocks are an accurate measure of biological aging and 'tick' slower in male sheep that are castrated.
    1. Genetics and Genomics
    2. Medicine

    Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

    Fernanda Morales Berstein, Daniel L McCartney ... Rebecca C Richmond
    GrimAge acceleration may increase the risk of colorectal cancer.

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