10,756 results found
    1. Neuroscience

    Inferring synaptic inputs from spikes with a conductance-based neural encoding model

    Kenneth W Latimer, Fred Rieke, Jonathan W Pillow
    The conductance-based encoding model creates a new bridge between statistical models and biophysical models of neurons, and infers visually-evoked excitatory and inhibitory synaptic conductances from spike trains in macaque retina.
    1. Physics of Living Systems

    Control of nuclear size by osmotic forces in Schizosaccharomyces pombe

    Joël Lemière, Paula Real-Calderon ... Fred Chang
    The volume of the nucleus is dictated by a balance of colloid osmotic forces from the nucleoplasm and cytoplasm.
    1. Evolutionary Biology

    Fog signaling has diverse roles in epithelial morphogenesis in insects

    Matthew Alan Benton, Nadine Frey ... Siegfried Roth
    Fog signaling with a narrow morphogenetic role in Drosophila has a deeply conserved function in epithelial morphogenesis across insects.
    1. Structural Biology and Molecular Biophysics

    Enabling X-ray free electron laser crystallography for challenging biological systems from a limited number of crystals

    Monarin Uervirojnangkoorn, Oliver B Zeldin ... William I Weis
    Post-refinement methods enable the use of X-ray free electron lasers for biological crystallography of systems in which sample quantity is a limitation.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Conformational changes in twitchin kinase in vivo revealed by FRET imaging of freely moving C. elegans

    Daniel Porto, Yohei Matsunaga ... Hang Lu
    Quantitative FRET imaging in moving C. elegans shows that stretch-unfolding of twitchin kinase occurs in the active muscle, whereby mechanical activity titrates the signaling pathway of this cytoskeletal kinase.
    1. Neuroscience

    Dopamine enhances model-free credit assignment through boosting of retrospective model-based inference

    Lorenz Deserno, Rani Moran ... Raymond J Dolan
    Cooperation between model-free and model-based control systems is boosted by enhancing dopamine levels.
    1. Cell Biology
    2. Physics of Living Systems

    Bridging the gap between single-cell migration and collective dynamics

    Florian Thüroff, Andriy Goychuk ... Erwin Frey
    A computational model, based on single-cell features like contractility and polarizability, quantitatively describes cellular dynamics from the single cell level up to small cohorts and confluent tissues.
    1. Structural Biology and Molecular Biophysics

    DeepFRET, a software for rapid and automated single-molecule FRET data classification using deep learning

    Johannes Thomsen, Magnus Berg Sletfjerding ... Nikos S Hatzakis
    An open-source user-friendly toolbox implementing machine learning for single-molecule FRET analysis enabling experts and non-experts to reproducibly provide dynamic structural biology insights.
    1. Structural Biology and Molecular Biophysics

    Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas

    Alison B Hickman, Shweta Kailasan ... Fred Dyda
    The tetrameric structure of a casposase bound to DNA and its biochemical properties show how a transposase could have evolved to perform CRISPR-Cas spacer acquisition.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Remote immune processes revealed by immune-derived circulating cell-free DNA

    Ilana Fox-Fisher, Sheina Piyanzin ... Yuval Dor
    Cell-free DNA methylation markers allow monitoring of immune and inflammatory cell turnover.

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