An innovative strategy in genome analysis has generated a detailed description of how pathogens mutate when facing human genetic diversity.

The evolution columbine genus involved frequent mixing between incipient species, and one chromosome appears to have taken its own path.

Associations can be mapped using k-mer frequencies in sequencing reads without prior sequencing of a reference genome enabling detection of associations to variants of multiple types and outside of the reference.

Detailed analysis of umbilical cord cells shows that the associations between DNA methylation, gene expression and genetic variation are complex and context-dependent.

Sequence changes in the pneumococcal genome explain most of the variability in duration of asymptomatic carriage with serotype, antibiotic resistance and prophage accounting for the largest effects.

Plasmodium falciparum kelch13 mutations that cause artemisinin resistant malaria in Southeast Asia show markedly different patterns of evolutionary selection in Africa.

Dosage-compensated gene expression facilitates chromosomal aneuploidy, which presents a rapid route to phenotypic evolution in natural yeast isolates.

Trans genetic variation in TdT and Artemis loci impacts V(D)J recombination probabilities.

Genome sequencing of mice selected for longer limbs reveals that rapid selection response is due to both discrete loci and polygenic adaptation.

Genes located within cellular organelles impact phenotype more than expected due to their interactions with nuclear genes.