46 results found
    1. Cell Biology
    2. Computational and Systems Biology

    Nonlinear feedback drives homeostatic plasticity in H2O2 stress response

    Youlian Goulev, Sandrine Morlot ... Gilles Charvin
    Nonlinear H2O2 scavenging by peroxiredoxins drives acquired stress resistance and replicative lifespan hormesis.
    1. Cell Biology

    High and stable ATP levels prevent aberrant intracellular protein aggregation in yeast

    Masak Takaine, Hiromi Imamura, Satoshi Yoshida
    The first demonstration that cellular ATP homeostasis suppresses high volatility of cellular ATP levels to ensure proteostasis that prevents accumulation of cytotoxic protein aggregation.
    1. Cell Biology

    Connexin 43 hemichannels regulate mitochondrial ATP generation, mobilization, and mitochondrial homeostasis against oxidative stress

    Jingruo Zhang, Manuel A Riquelme ... Jean X Jiang
    Mitochondrial Cx43 hemichannels regulate ATP generation by mediating K+, H+, and ATP transfer across the mitochondrial inner membrane and the interaction with mitochondrial ATP synthase, contributing to maintenance of mitochondrial redox and cell protection under oxidative stress.
    1. Cell Biology
    2. Genetics and Genomics

    Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative phosphorylation

    Simon Stenberg, Jing Li ... Jonas Warringer
    Yeast cells adapt to harmful superoxide generated during mitochondrial oxidative phosphorylation by arresting respiration through mtDNA deletions whose emergence depend on superoxide dismutase 2 and the retrograde pathway.
    1. Cell Biology
    2. Neuroscience

    HIF1α stabilization in hypoxia is not oxidant-initiated

    Amit Kumar, Manisha Vaish ... Rajiv R Ratan
    The current findings address the redox regulation of hypoxia inducible factor 1α (HIF1α) stability in hypoxia by showing that cytosolic, mitochondrial or lipid ROS are not necessary for HIF1α stabilization in hypoxia.
    1. Microbiology and Infectious Disease

    Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis

    Somnath Shee, Reshma T Veetil ... Amit Singh
    Genome-scale integration of transposon mutagenesis with a redox biosensor identified a hypothetical transcription factor- Rv0158 required to calibrate the growth, cytoplasmic redox potential, and respiration of Mycobacterium tuberculosis in response to metabolic switching from glucose to fatty acids.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A

    Friederike Roger, Cecilia Picazo ... Mikael Molin
    The major cytosolic yeast peroxiredoxin Tsa1 controls aging and H2O2-resistance by inhibiting protein kinase A through a conserved cysteine in the catalytic subunit activation loop and not by scavenging H2O2.
    1. Cell Biology

    Protective mitochondrial fission induced by stress-responsive protein GJA1-20k

    Daisuke Shimura, Esther Nuebel ... Robin M Shaw
    Stress-induced alternative translation of an otherwise common gap junction protein generates an isoform that orchestrates protective mitochondrial fission and organ protection during anticipated ischemia.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Free spermidine evokes superoxide radicals that manifest toxicity

    Vineet Kumar, Rajesh Kumar Mishra ... Dipak Dutta
    Spermidine-mediated superoxide generation affects iron homeostasis in Escherichia coli.
    1. Microbiology and Infectious Disease

    Redox controls RecA protein activity via reversible oxidation of its methionine residues

    Camille Henry, Laurent Loiseau ... Benjamin Ezraty
    RecA is inactivated by oxidative stress and repaired by the MsrA/B anti-ROS defense system.

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