1,751 results found
    1. Developmental Biology
    2. Neuroscience

    Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes

    Tuo Shi, Marielle O Beaulieu ... David W Raible
    Single-cell transcriptomic analysis defines hair cell and supporting cell types in the zebrafish inner ear, and reveals homologies with cells in the mammalian ear.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

    Louise Menendez, Talon Trecek ... Neil Segil
    Direct reprogramming of somatic cells to an inner ear sensory hair cell-like state provides an experimental platform to identify causes and treatments for hair cell loss and hearing deficits.
    1. Neuroscience
    2. Physics of Living Systems

    Rapid mechanical stimulation of inner-ear hair cells by photonic pressure

    Sanjeewa Abeytunge, Francesco Gianoli ... Andrei S Kozlov
    A new method is described to apply rapid and uniform mechanical forces to vestibular and cochlear hair cells.
    1. Cell Biology
    2. Developmental Biology

    Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure

    Ian A Swinburne, Kishore R Mosaliganti ... Sean G Megason
    The pressure of fluid in the inner ear is controlled by opening of cellular valves in the endolymphatic sac to allow for regulated transepithelial fluid flow.
    1. Developmental Biology
    2. Neuroscience

    Molecular architecture underlying fluid absorption by the developing inner ear

    Keiji Honda, Sung Huhn Kim ... Andrew J Griffith
    Genome-wide RNA-seq analysis of single cells of the developing mouse endolymphatic sac reveals its molecular-cellular architecture and a model for salt and fluid absorption required for acquisition of normal inner ear structure and function.
    1. Developmental Biology

    A gradient of Wnt activity positions the neurosensory domains of the inner ear

    Magdalena Żak, Nicolas Daudet
    Manipulations of Wnt signalling in the chicken embryo reveal how it controls in a dose-dependent manner the formation of the neurosensory territories of the early developing inner ear.
    1. Cell Biology
    2. Developmental Biology

    Distribution of neurosensory progenitor pools during inner ear morphogenesis unveiled by cell lineage reconstruction

    Sylvia Dyballa, Thierry Savy ... Cristina Pujades
    The first dynamic map of early neuronal and sensory progenitors in the whole otic vesicle reveals how progenitor domains remodel upon morphogenesis.
    1. Developmental Biology

    Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a

    Zoe F Mann, Héctor Gálvez ... Nicolas Daudet
    A dynamic confrontation between Notch signalling and the transcription factor Lmx1a at the borders of the developing inner ear sensory patches regulates their segregation and the positioning of their boundaries.
    1. Computational and Systems Biology
    2. Developmental Biology

    Size control of the inner ear via hydraulic feedback

    Kishore R Mosaliganti, Ian A Swinburne ... Sean G Megason
    Size regulation of the otic vesicle, the progenitor of the inner ear, is mediated by mechanical feedback involving fluid influx, hydraulic pressure, and tissue mechanics.
    1. Developmental Biology
    2. Neuroscience

    Comprehensive transcriptome analysis of cochlear spiral ganglion neurons at multiple ages

    Chao Li, Xiang Li ... Zhiyong Liu
    RNA-Seq analysis and in vivo validation via genetic approach uncover that Scrt2 and Celf4 are expressed in inner ear auditory neurons throughout development.

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