The structure of the promising malaria blood-stage vaccine candidate antigen PfCyRPA and the characterization of a protective epitope are facilitating research on its essential role in parasite invasion, and will guide future epitope-focused vaccine design.

The crystal structures of the key vaccine candidate CyRPA alone and in complex with antibody Fab fragment was solved and this will be important information for designing a vaccine.

Plasmodium falciparum invasion protein EBA-175, once shed from the parasite surface post invasion, facilitates RBC clustering and enhances parasite growth while simultaneously enabling parasite immune evasion of host neutralizing antibodies.

The most effective growth-neutralising antibodies which target the PfRH5 protein from a malaria parasite function by preventing the parasite from binding to basigin-containing membrane protein complexes on human erythrocytes.

Optimised genome editing in P. knowlesi enables transgenic expression of a lead P. vivax vaccine candidate, revealing roles in host cell tropisms and providing tools for scalable vaccine efficacy testing.

The strain-transcendent receptor CD55 plays a distinct functional role relative to other known receptors for Plasmodium falciparum invasion of human erythrocytes, indicating it may present a vulnerable target for intervention.

GDE3 is a transmembrane GPI-specific phospholipase C that sheds the urokinase receptor (uPAR) from the cell surface resulting in loss of uPAR function in breast cancer cells and reduced tumor growth.

Specific localization of KRAS downstream target ARL4C with its novel interacting proteins was the active site of invasion of pancreatic cancer cell and induced metastasis.

Biophysical and structural studies reveal how two inhibitory antibodies targeting CSP on malaria-causing Plasmodium vivax parasites lock its intrinsically flexible repeat into predominant coiled conformations, contributing molecular details of Pv inhibition by antibodies to enable structure-based engineering of PvCSP-based vaccines.

Antibody responses to individual and optimal combinations of P. vivax recombinant proteins in naturally-exposed populations help to identify correlates of protective immunity, and establish a clear path to testing a multicomponent P. vivax vaccine.