125 results found
    1. Structural Biology and Molecular Biophysics

    Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels

    Yiming Niu, Xiao Tao ... Roderick MacKinnon
    The structural role of PIP2 in opening the G-protein-gated K+ channel is revealed.
    1. Genetics and Genomics
    2. Structural Biology and Molecular Biophysics

    Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning

    Willow Coyote-Maestas, David Nedrud ... Daniel Schmidt
    By measuring the impacts of thousands of mutations on potassium channel trafficking and function, we illuminate the molecular basis of folding, structure–function relationships, and how these are altered in disease.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Molecular structure of human KATP in complex with ATP and ADP

    Kenneth Pak Kin Lee, Jue Chen, Roderick MacKinnon
    MgADP binding to the high-affinity 'consensus' ATPase active site of SUR1 and remodeling of the L0-loop (lasso region) overrides tonic ATP inhibition of KATP channels.
    1. Structural Biology and Molecular Biophysics

    Ion Channels: From ions to insulin

    Voula Kanelis
    Electron cryo-microscopy has revealed the three-dimensional structure of a potassium channel that has a central role in regulating the release of insulin from the pancreas.
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    1. Neuroscience

    Shallow neural networks trained to detect collisions recover features of visual loom-selective neurons

    Baohua Zhou, Zifan Li ... Damon A Clark
    When artificial networks modeled on a Drosophila neuron are tasked with discriminating objects on collision course from other visual scenes, their optimized solutions reproduce many functional features of the original loom-selective neuron.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

    Gregory M Martin, Craig Yoshioka ... Show-Ling Shyng
    Single-particle cryo-electron microscopy reveals the first subnanometer structure of ATP-sensitive potassium (KATP) channels, which provides insight into the structural mechanisms of channel assembly and gating.
    1. Structural Biology and Molecular Biophysics

    Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

    Gregory M Martin, Min Woo Sung ... Show-Ling Shyng
    Diverse KATP channel inhibitors occupy a common binding pocket and stabilize an interaction between Kir6.2 and SUR1 to allosterically control gating and promote the assembly and trafficking of nascent channels.
    1. Neuroscience

    Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity

    Juliette Boeri, Claude Meunier ... Antonny Czarnecki
    A simple mechanism, based on the synergy of two major opposing voltage-dependent currents that are ubiquitous in neurons, produces functional diversity of developing Renshaw cells in the embryo.
    1. Cell Biology
    2. Neuroscience

    Optogenetic manipulation of Gq- and Gi/o-coupled receptor signaling in neurons and heart muscle cells

    Hanako Hagio, Wataru Koyama ... Masahiko Hibi
    Animal G-protein-coupled bistable rhodopsins can regulate Gq- and Gi-mediated signaling in a light-dependent manner in neurons and cardiomyocytes, making them useful for analyzing the roles of GPCR signaling in vivo.

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