407 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Hedgehog regulation of epithelial cell state and morphogenesis in the larynx

    Janani Ramachandran, Weiqiang Zhou ... Steven A Vokes
    HH signaling prevents precocious EMT and cell death to maintain epithelial cell states during early stages of larynx development.
    1. Stem Cells and Regenerative Medicine

    Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria

    Carolyn E Adler, Chris W Seidel ... Alejandro Sánchez Alvarado
    A chemical method has been developed for studying single organ regeneration and fate specification of stem cells in an adult organism.
    1. Developmental Biology

    Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx

    Jacqueline M Tabler, Maggie M Rigney ... John B Wallingford
    Genetic studies in mice reveal the molecular and embryological mechanisms of vocal fold development and function, thereby informing our understanding of vocal communication and congenital voice defects.
    1. Genetics and Genomics
    2. Neuroscience

    FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons

    Caryn R Hale, Kirsty Sawicka ... Robert B Darnell
    Combining compartment- and cell-type specific transcriptomic approaches reveals FMRP regulation of synaptic regulators in the dendrites and chromatin regulators in the cell bodies of CA1 neurons.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    MYOD1 functions as a clock amplifier as well as a critical co-factor for downstream circadian gene expression in muscle

    Brian A Hodge, Xiping Zhang ... Karyn A Esser
    The myogenic lineage transcription factor, MYOD1, amplifies and works with the core clock factors to support a daily muscle gene expression program.
    1. Cell Biology

    The skeletal muscle circadian clock regulates titin splicing through RBM20

    Lance A Riley, Xiping Zhang ... Karyn A Esser
    The muscle circadian clock regulates RNA-binding motif 20 (Rbm20) gene expression, providing a novel mechanism for titin splicing and isoform expression with implications for muscle structure and function.
    1. Neuroscience

    State transitions in the substantia nigra reticulata predict the onset of motor deficits in models of progressive dopamine depletion in mice

    Amanda M Willard, Brian R Isett ... Aryn H Gittis
    The transition in basal ganglia output from the healthy to the diseased state is biphasic, stereotyped across models, and suggests key time points for delivering therapeutic interventions.
    1. Neuroscience

    Phasic and tonic neuron ensemble codes for stimulus-environment conjunctions in the lateral entorhinal cortex

    Maryna Pilkiw, Nathan Insel ... Kaori Takehara-Nishiuchi
    Neuron populations in the lateral entorhinal cortex discriminate between memory-based contexts through both continuous "tonic" activity patterns as well as by their stimulus-evoked "phasic" responses.
    1. Cell Biology

    NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice

    James Anthony Loehr, Shang Wang ... George G Rodney
    Reative oxygen species modulate microtubules and diaphragm function.
    1. Developmental Biology

    Crosstalk between nitric oxide and retinoic acid pathways is essential for amphioxus pharynx development

    Filomena Caccavale, Giovanni Annona ... Salvatore D'Aniello
    Previously undescribed morphogenetic and developmental mechanisms unravel that the cooperation of two ancient signaling pathways, nitric oxide and retinoic acid, is essential to build a chordate embryo.

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