1,541 results found
    1. Epidemiology and Global Health

    Vitamin A supplements, routine immunization, and the subsequent risk of Plasmodium infection among children under 5 years in sub-Saharan Africa

    Maria-Graciela Hollm-Delgado, Frédéric B Piel ... Robert E Black
    An analysis of national survey data shows that vitamin A might protect against malaria infection, an effect potentially modified by seasonality, and that no routine vaccinations were linked to parasitemia, though BCG vaccination was associated with PfHRP-2 antigenemia.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

    James A Watson, Carolyne M Ndila ... Nicholas J White
    Complete blood count data can increase the accuracy of the diagnosis of severe malaria in children in high transmission settings.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea

    Natalie E Hofmann, Stephan Karl ... Ivo Mueller
    Under sustained malaria control in PNG, the incidence of distinct blood-stage infections quantifies heterogeneity in transmission, significantly predicting risk of both P. falciparum and P. vivax malaria episodes at a population and individual scale.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    The Dantu blood group prevents parasite growth in vivo: Evidence from a controlled human malaria infection study

    Silvia N Kariuki, Alexander W Macharia ... Thomas N Williams
    Strongly protective effect conferred by the Dantu blood group variant against early, non-clinical, Plasmodium falciparum malaria infections in vivo.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α+thalassaemia

    D Herbert Opi, Olivia Swann ... J Alexandra Rowe
    Analysis of a large Kenyan dataset may resolve previously conflicting studies by identifying polymorphisms which interact to modify the risk of cerebral malaria.
    1. Epidemiology and Global Health

    Evidence from a natural experiment that malaria parasitemia is pathogenic in retinopathy-negative cerebral malaria

    Dylan S Small, Terrie E Taylor ... Karl B Seydel
    The sickle cell trait strongly protects against not only retinopathy-positive cerebral malaria but also retinopathy-negative cerebral malaria, providing evidence that malarial parasites also contribute to retinopathy-negative cerebral malaria and are not innocent bystanders.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

    Geraldine M Clarke, Kirk Rockett ... MalariaGEN Consortium
    Increasing levels of glucose-6-phosphate dehydrogenase deficiency are associated with decreasing risk of cerebral malaria, but with increased risk of severe malarial anaemia.
    1. Microbiology and Infectious Disease

    A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi

    Annemarie Voorberg-van der Wel, Guglielmo Roma ... Thierry Tidiane Diagana
    This comprehensive transcriptomic resource of dormant and replicating malaria liver parasites highlights the dearth of pathways that operate in the hypnozoites and the need to investigate druggability (i.e. selectivity and safety) of core pathways in malaria parasites.
    1. Microbiology and Infectious Disease
    2. Medicine

    A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

    Isaie J Reuling, Lisanne A van de Schans ... Teun Bousema
    Controlled human malaria infection model allows the study of gametocyte biology and dynamics providing novel insights and tools in malaria transmission and elimination efforts.
    1. Epidemiology and Global Health

    Relationship between changing malaria burden and low birth weight in sub-Saharan Africa: A difference-in-differences study via a pair-of-pairs approach

    Siyu Heng, Wendy P O'Meara ... Dylan S Small
    A novel pair-of-pairs matching approach finds that community-level reductions in malaria burden can potentially substantially reduce the low birth weight rate in sub-Saharan Africa, particularly among firstborns.

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