2,814 results found
    1. Neuroscience

    A size principle for recruitment of Drosophila leg motor neurons

    Anthony W Azevedo, Evyn S Dickinson ... John C Tuthill
    Motor neurons controlling the leg of the fruit fly exhibit a gradient of physiological and functional properties that correlate with the order in which they fire during behavior.
    1. Developmental Biology
    2. Neuroscience

    Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

    Ya-Ping Yen, Wen-Fu Hsieh ... Jun-An Chen
    LncRNAs are important to stabilize postmitotic cell fate of spinal motor neurons.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons

    Disi An, Ryosuke Fujiki ... Esteban Orlando Mazzoni
    Stem cell-derived motor neurons with differential ALS vulnerability identified proteasome activity as a possible mechanism that explains their differential sensitivity.
    1. Stem Cells and Regenerative Medicine

    Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model

    Hyunah Lee, Hye Yeong Lee ... Jeong Beom Kim
    Sequential introduction of transcription factors enables large-scale generation of induced motor neurons (iMNs) from human somatic cells, and transplantation of iMNs exhibit therapeutic effects in spinal cord injury model.
    1. Developmental Biology
    2. Neuroscience

    Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity

    Catarina Catela, Yihan Chen ... Paschalis Kratsios
    Molecular, genetic, and behavioral assays in mice establish a new role for Hox proteins in the final steps of spinal motor neuron development.
    1. Neuroscience

    Organelle calcium-derived voltage oscillations in pacemaker neurons drive the motor program for food-seeking behavior in Aplysia

    Alexis Bédécarrats, Laura Puygrenier ... Romuald Nargeot
    An atypical neuronal pacemaker mechanism triggers feeding motor pattern in Aplysia..
    1. Neuroscience

    Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response

    Katherine Cora Ames, Mark M Churchland
    Neurons in motor cortex contain information about each arm, but these signals are separated into different dimensions, allowing separate control of each arm.
    1. Neuroscience
    2. Developmental Biology

    Phrenic-specific transcriptional programs shape respiratory motor output

    Alicia N Vagnozzi, Kiran Garg ... Polyxeni Philippidou
    Molecular programs regulated by Hox5 transcription factors establish a set of inhibitory inputs onto phrenic motor neurons that control the pattern of respiratory motor output.
    1. Neuroscience

    The critical role of membralin in postnatal motor neuron survival and disease

    Bo Yang, Mingliang Qu ... Dongxian Zhang
    Membralin mutant mice manifest a severe and early-onset motor neuron disease with defects in endoplasmic reticulum-associated protein degradation.
    1. Developmental Biology
    2. Neuroscience

    Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships

    Julia L Meng, Yupu Wang ... Ellie S Heckscher
    Acting in neuronal stem cells, temporal transcription factors, as a class of molecules, are uniquely potent determinants of circuit membership that establish expected patterns of wiring in the motor system.

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