497 results found
    1. Neuroscience

    PBN-PVT projections modulate negative affective states in mice

    Ya-Bing Zhu, Yan Wang ... Di Mu
    The parabrachial nucleus-thalamic paraventricular nucleus pathway is critical for modulating affective states in mice.
    1. Neuroscience

    Distinct roles of NMDA receptors at different stages of granule cell development in the adult brain

    Yangling Mu, Chunmei Zhao ... Fred H Gage
    NMDARs promote spine formation to control survival of adult-born granule cells, but gauge spine enlargement and recruitment of AMPARs in both developing and mature neurons.
    1. Neuroscience

    Brain-wide mapping of neural activity controlling zebrafish exploratory locomotion

    Timothy W Dunn, Yu Mu ... Misha B Ahrens
    Whole-brain activity imaging in larval zebrafish reveals brain regions that influence patterns of spontaneous movement to increase local exploration efficiency.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress

    Megan C Kopp, Piotr R Nowak ... Maruf MU Ali
    Quantitative FRET UPR induction assay is used to measure IRE1 and BIP association and dissociation by a variety of ER misfolded proteins and by an important BiP substrate-binding domain mutant, significantly enhancing the evidence for the allosteric UPR induction model.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling

    Marta Carrara, Filippo Prischi ... Maruf MU Ali
    The chaperone protein BiP forms complexes with Ire1 and Perk that dissociate when unfolded proteins bind to BiP to activate the unfolded protein response in the ER.
    1. Developmental Biology

    Chloride channels regulate differentiation and barrier functions of the mammalian airway

    Mu He, Bing Wu ... Lily Yeh Jan
    The chloride channel Ano1/Tmem16a plays an essential and non-redundant role in the developing airway by inhibiting mucus cell hyperplasia and promoting proper immune function of the airway mucosal barrier.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Target DNA bending by the Mu transpososome promotes careful transposition and prevents its reversal

    James R Fuller, Phoebe A Rice
    Biochemical data demonstrate that the conformation of the target site DNA can dramatically modulate the kinetics and directionality of the otherwise isoenergetic transposition reaction of DDE transposases.
    1. Ecology
    2. Neuroscience

    Individual recognition and the ‘face inversion effect’ in medaka fish (Oryzias latipes)

    Mu-Yun Wang, Hideaki Takeuchi
    Medaka fish were able to use faces for individual recognition, and were slower to recognise inverted faces but not inverted non-face shapes.
    1. Neuroscience

    TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala

    Ke-Xin Li, Mu He ... Lily Yeh Jan
    SOM+ GABAergic neuronal signaling and inhibitory transmission in the central lateral amygdala is regulated by TMEM16B, which is also involved in fear and anxiety-like behaviors.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Deep learning-driven insights into super protein complexes for outer membrane protein biogenesis in bacteria

    Mu Gao, Davi Nakajima An, Jeffrey Skolnick
    An example of a deep learning-based strategy to discover novel protein-protein interactions and predict their complex structures at high accuracy.

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