The Atlantic herring has the lowest mutation rate yet estimated in a vertebrate species and this partially explains its moderate nucleotide diversity given the large population size.
A broad mutational target is the cause of the high mutational variance and corresponding fast phenotypic evolutionary rate in P3.p cell fate in Caenorhabditis nematodes.
Quantitative proteomic analysis shows that recessive Ryr1 mutations not only decrease the content of RyR1 protein in muscle, but also affect the content of many other proteins involved in a variety of biological processes.
Alayne Cuzick, James Seager ... Kim E Hammond-Kosack
A framework has been devised that enables global participation in the curation of publications on any topic involving two or more living organisms, ranging from microscopic to larger sizes, in their natural or artificial environments or ecosystems.
Whole genome DNA sequence analysis, genome wide gene expression and complex organismal phenotypes in Drosophila mutation accumulation lines provide a robust estimate of the spontaneous mutation rate and mutational effects.
A new framework for mutation spectrum analysis reveals multiple independent changes in the germline mutation patterns of human populations, which cannot be explained by shifts in average ages at reproduction.
Thomas A Sasani, Brent S Pedersen ... Aaron R Quinlan
Rates of germline mutation accumulation are highly variable across families of similar genetic ancestry, and post-zygotic mosaicism is a substantial source of de novo mutations.
Germline mutation rates in mice are shaped by two mutator alleles that interact epistatically, showing that DNA repair defects that map to different loci can have snowballing effects.
Deep mutational scanning was used to comprehensively quantify the effects of mutations to influenza hemagglutinin and shows that the virus possesses a high inherent mutational tolerance at key antigenic sites.
