3,779 results found
    1. Neuroscience

    Neuronal variability and tuning are balanced to optimize naturalistic self-motion coding in primate vestibular pathways

    Diana E Mitchell, Annie Kwan ... Kathleen E Cullen
    A match between neuronal variability and tuning enables optimized coding of natural self-motion in early vestibular pathways.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain

    Claudia Scheckel, Elodie Drapeau ... Robert B Darnell
    Neuronal ELAV-like (nELAVL) proteins are associated with non-coding Y RNAs in stressed neurons and in the brains of Alzheimer's disease patients, suggesting a new means of regulatory protein sequestration and mRNA target regulation.
    1. Neuroscience

    Specialized coding patterns among dorsomedial prefrontal neuronal ensembles predict conditioned reward seeking

    Roger I Grant, Elizabeth M Doncheck ... James M Otis
    Excitatory output neurons in dorsomedial prefrontal cortex display heterogeneously specialized coding properties that evolve during cue-reward learning and predict cue-driven reward seeking.
    1. Computational and Systems Biology
    2. Neuroscience

    Principles for coding associative memories in a compact neural network

    Christian Pritz, Eyal Itskovits ... Alon Zaslaver
    A compact neural network can form various associative memories that are encoded in a distributed manner, where each neuron stores different components of the memory.
    1. Genetics and Genomics

    Neurodevelopmental Disorders: Beyond protein-coding genes

    Anna Lozano-Ureña, Sacri R Ferrón
    A long non-coding RNA called lnc-NR2F1 regulates several neuronal genes, including some involved in autism and intellectual disabilities.
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    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

    Cheen Euong Ang, Qing Ma ... Howard Y Chang
    lnc-Nr2f1, a long non-coding RNA focally deleted in autism patients, directly occupies and regulates neuronal genes.
    1. Neuroscience

    Time encoding migrates from prefrontal cortex to dorsal striatum during learning of a self-timed response duration task

    Gabriela C Tunes, Eliezyer Fermino de Oliveira ... Marcelo Bussotti Reyes
    Electrophysiological and pharmacological data provide evidence that the medial prefrontal cortex is essential for rats to learn a timing task, becoming unnecessary later, while the dorsal striatum does not play a role initially, taking over when animals become proficient.
    1. Neuroscience

    Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates

    Amanda Klein, Hans Jürgen Solinski ... Matthias Ringkamp
    MRGPRD and MRGRPX1 are co-expressed in primate DRG neurons, but β-alanine and BAM8-22, preferentially activate CMH-subclasses, and co-activating different cutaneous nociceptors by pruritogens does not change itch sensation to pain.
    1. Neuroscience

    Sampling motion trajectories during hippocampal theta sequences

    Balazs B Ujfalussy, Gergő Orbán
    The rodent brain represents uncertainty associated with short-term predictions during naturalistic navigation tasks sequentially by sampling hypothetical future trajectories in every ~100 ms, corresponding to successive theta cycles.
    1. Neuroscience

    A general decoding strategy explains the relationship between behavior and correlated variability

    Amy M Ni, Chengcheng Huang ... Marlene R Cohen
    The frequently observed relationship between perceptual performance and correlated variability in sensory cortex can be explained by observers using a decoding strategy that prioritizes generality for many stimuli over precision.

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