Iga Kucharska, Elaine Thai ... Jean-Philippe Julien
A comprehensive structural analysis of inhibitory murine antibody 3D11 binding to Plasmodium berghei circumsporozoite protein reveals common mechanisms of antibody evolution in mammals against Plasmodium parasites.
CDPK4 is a pleiotropic regulator controlling initiation of DNA replication, mitotic spindle assembly and flagellar activation during the early stages of Plasmodium transmission.
Adam J Reid, Arthur M Talman ... Mara KN Lawniczak
Plasmodium parasite transcription shifts dramatically along asexual development, and transmission stages variably express important immune evasion genes, suggesting much interesting biology has until now been hidden by bulk analyses.
Iga Kucharska, Lamia Hossain ... Jean-Philippe Julien
Biophysical and structural studies reveal how two inhibitory antibodies targeting CSP on malaria-causing Plasmodium vivax parasites lock its intrinsically flexible repeat into predominant coiled conformations, contributing molecular details of Pv inhibition by antibodies to enable structure-based engineering of PvCSP-based vaccines.
Structures of a gamete fusogen and antibody fragments bound to its domain 3, and inhibition of parasite fertilization, bring us closer to creating a vaccine to block transmission by mosquitoes of malaria from one person to another.
Host CD81 and Scavenger Receptor BI operate independently to mediate invasion of hepatocytes by different species of Plasmodium sporozoites, which use the parasite protein P36 as a key determinant of the entry route.
Ellie Sherrard-Smith, Katarzyna A Sala ... Andrew M Blagborough
Combining pre-erythrocytic and transmission blocking antibodies enhances the overall control and potential elimination of malaria within both mosquito and vertebrate populations.