166 results found
    1. Genetics and Genomics

    Transgenesis and web resources in quail

    Olivier Serralbo, David Salgado ... Christophe Marcelle
    Transfection of quail primordial germ cells considerably expands the possibilities of genome modifications in birds, elevating the quail to the rank of genetic laboratory animal models of reference.
    1. Neuroscience

    FSHβ links photoperiodic signaling to seasonal reproduction in Japanese quail

    Gaurav Majumdar, Timothy A Liddle ... Tyler Stevenson
    Molecular analyses reveal the neuroendocrine control of seasonal life-history transitions in birds.
    1. Developmental Biology

    Transgenic quails reveal dynamic TCF/β-catenin signaling during avian embryonic development

    Hila Barzilai-Tutsch, Valerie Morin ... Olivier Serralbo
    A novel avian transgenic line allows studying the function of Wnt signaling during embryonic development.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner

    Stefan Golfier, Thomas Quail ... Jan Brugués
    Reconstitution of DNA loop extrusion in cellular contexts using Xenopus egg extracts shows that condensin extrudes DNA loops non-symmetrically in metaphase, whereas cohesin extrudes DNA loops symmetrically in interphase.
    1. Developmental Biology

    Species-specific sensitivity to TGFβ signaling and changes to the Mmp13 promoter underlie avian jaw development and evolution

    Spenser S Smith, Daniel Chu ... Richard A Schneider
    Multiple levels of gene regulation in the TGFβ signaling pathway mediate the expression of Mmp13, establish species-specific domains of bone resorption, and likely generate evolutionary variation in jaw length.
    1. Developmental Biology
    2. Evolutionary Biology

    Coronary artery established through amniote evolution

    Kaoru Mizukami, Hiroki Higashiyama ... Hiroki Kurihara
    During the evolution of amniotes, the transformation of branchial arches coincided with the drastic remodeling of the ancestral extrinsic cardiac arteries, giving rise to novel ventricular coronary arteries that are unique to amniotes.
    1. Developmental Biology

    Completion of neural crest cell production and emigration is regulated by retinoic-acid-dependent inhibition of BMP signaling

    Dina Rekler, Chaya Kalcheim
    BMP-dependent retinoic acid signaling is responsible for the separation of central from peripheral lineages during neural development.
    1. Stem Cells and Regenerative Medicine

    Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians

    Jordi Solana, Manuel Irimia ... Nikolaus Rajewsky
    A conserved alternative splicing program is specific to planarian stem cells and is controlled by the highly conserved splicing factors CELF and MBNL; therefore, this mode of regulating stem cells is likely ancestral to all animals.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Patterns of within-host genetic diversity in SARS-CoV-2

    Gerry Tonkin-Hill, Inigo Martincorena ... Wellcome Sanger Institute COVID-19 Surveillance Team
    Characterisation of within-host diversity of SARS-CoV-2 provides insights into the mutational and selective mechanisms driving its evolution and has important implications for using within-host variation to inform transmission inference efforts.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. elegans

    Gregory M Davis, Shikui Tu ... Peter R Boag
    The RNA-binding protein NHL-2 is required for small-RNA mediated transgenerational epigenetic gene regulation.

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