383 results found
    1. Stem Cells and Regenerative Medicine

    Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche

    Su Wang, Yuan Gao ... Ting Xie
    Wnt signaling regulates cellular redox in the germline stem cell differentiation niche via a novel regulatory mechanism, thereby controlling germ line stem cell progeny differentiation.
    1. Biochemistry and Chemical Biology

    Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose control

    Meiling Wu, Anda Zhao ... Dongyun Shi
    Moderate exercise upregulated compensatory antioxidant capability and reached a high-level redox balance, whereas antioxidant intervention achieved a low-level redox balance by inhibiting oxidative stress for treating diabetes.
    1. Plant Biology

    Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors

    Alexey Shapiguzov, Julia P Vainonen ... Jaakko Kangasjärvi
    Signalling and metabolic interactions of the plant energy organelles, chloroplasts and mitochondria, depend on the nuclear regulatory protein RCD1.
    1. Cancer Biology
    2. Cell Biology

    NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans

    Collin Yvès Ewald, John M Hourihan ... Nancy E Hynes
    Genetic analysis reveals NADPH oxidase generated reactive oxygen species as signals to re-establish cellular homeostasis during aging via activating a transcriptional response.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress

    Jie Wang, Kristeen A Pareja ... Carolyn S Sevier
    Direct modification by endogenous peroxide of a conserved cysteine in the molecular chaperone BiP decouples its ATPase and peptide-binding activities, allowing for enhanced polypeptide holdase activity during oxidative stress.
    1. Neuroscience
    2. Cell Biology

    Redox regulation of KV7 channels through EF3 hand of calmodulin

    Eider Nuñez, Frederick Jones ... Alvaro Villarroel
    Calmodulin mediates in the protective augmentation of KV7-currents in response to oxidative stress in a calcium-dependent manner by an unconventional signaling mechanism.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A

    Friederike Roger, Cecilia Picazo ... Mikael Molin
    The major cytosolic yeast peroxiredoxin Tsa1 controls aging and H2O2-resistance by inhibiting protein kinase A through a conserved cysteine in the catalytic subunit activation loop and not by scavenging H2O2.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis

    Virender Kumar Pal, Ragini Agrawal ... Amit Singh
    A gaseous signaling molecule hydrogen sulfide stimulates mitochondrial bioenergetics, maintains glutathione redox poise, and suppresses ROS to subvert viral rebound in latently infected CD4+ T cells from HIV subjects.
    1. Immunology and Inflammation

    Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation

    Jaime James, Yifei Chen ... Rikard Holmdahl
    PTPN22 function is regulated by reactive oxygen species, and redox regulation of PTPN22 impacts T-cell-dependent autoimmune inflammation.

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