7 results found
    1. Developmental Biology

    Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes

    Dorit Hockman, Alan J Burns ... Clare V H Baker
    Embryonic fate-mapping approaches in zebrafish, Xenopus and lamprey illuminate the evolutionary origins of carotid body glomus cells and pulmonary neuroendocrine cells.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Adult chondrogenesis and spontaneous cartilage repair in the skate, Leucoraja erinacea

    Aleksandra Marconi, Amy Hancock-Ronemus, J Andrew Gillis
    The ability of cartilaginous fishes to generate new cartilage through adulthood, and to spontaneously repair damaged cartilage, could shed light on novel cell-based therapies for cartilage injury in mammals.
    1. Developmental Biology

    Evolutionary Developmental Biology: Sensing oxygen inside and out

    Maria R Stupnikov, Wellington V Cardoso
    Neuroendocrine cells act as oxygen sensors in animals from fish to humans, but the evolutionary origins of these cells are only just becoming clear.
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    1. Developmental Biology
    2. Evolutionary Biology

    A novel cis-regulatory element drives early expression of Nkx3.2 in the gnathostome primary jaw joint

    Jake Leyhr, Laura Waldmann ... Tatjana Haitina
    Jaw joint regulatory sequence 1 (JRS1) is deeply conserved in most jawed vertebrates and displays a specific enhancer activity in the developing primary jaw joint that contributes to early nkx3.2 gene expression and jaw joint morphology.
    1. Epidemiology and Global Health
    2. Medicine

    Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

    Manoj M Lalu, Katrina J Sullivan ... Lauralyn McIntyre
    A rigorous and transparent evaluation of mesenchymal stem cell therapy for sepsis suggests it may be efficacious, although the strength of these findings is tempered by threats to validity in the studies that were included.
    1. Evolutionary Biology

    Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm

    Ana B Tinoco, Antón Barreiro-Iglesias ... Maurice R Elphick
    Starfish feed by everting their stomach out of their mouth over prey and, interestingly, this unusual feeding mechanism is inhibited by substances similar to hormones that regulate feeding in humans.
    1. Evolutionary Biology

    Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases

    Hironori Funabiki, Isabel E Wassing ... Thomas Carroll
    Coevolution analysis suggests that a DNA methylation-related role for the nucleosome remodeling ATPase HELLS and its activator CDCA7 was broadly inherited from the last eukaryotic common ancestor.

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