144 results found
    1. Structural Biology and Molecular Biophysics

    Binding to nucleosome poises human SIRT6 for histone H3 deacetylation

    Ekaterina Smirnova, Emmanuelle Bignon ... Adam Ben Shem
    The dynamics of Sirtuin 6 binding to the nucleosome shed light on how it is able to deacetylate histone H3 lysines close to the core, including K27.
    1. Microbiology and Infectious Disease

    Host sirtuin 2 as an immunotherapeutic target against tuberculosis

    Ashima Bhaskar, Santosh Kumar ... Vinay Kumar Nandicoori
    The inhibition of host Sirtuin-2 by AGK2 restricts mycobacterial growth in vivo by modulation of host transcriptome leading to activation of protective immune responses.
    1. Biochemistry and Chemical Biology

    Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach

    Xiucong Bao, Yi Wang ... Xiang David Li
    Sirt3 functions as decrotonylase to regulate histone crotonylation dynamics.
    1. Biochemistry and Chemical Biology

    Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication

    Knut H Lauritzen, Maria Belland Olsen ... Arne Yndestad
    Transgenic mice and cell models provide evidence of a pathophysiological mechanism that connects mtDNA damage to cardiac dysfunction via reduced NAD+ levels and loss of mitochondrial function and communication.
    1. Cell Biology

    SIRT6 is a DNA double-strand break sensor

    Lior Onn, Miguel Portillo ... Debra Toiber
    Hundreds of proteins are involved in the DNA damage response but only three sensors for DSB were known but now SIRT6 is identified as a fourth DSB sensor.
    1. Medicine

    SIRT2 inhibition protects against cardiac hypertrophy and ischemic injury

    Xiaoyan Yang, Hsiang-Chun Chang ... Hossein Ardehali
    SIRT2 has detrimental effects in the heart and plays a role in cardiac response to injury and the progression of cardiac hypertrophy, and targeting SIRT2 may provide a novel avenue for the treatment of cardiac hypertrophy and ischemic disease.
    1. Chromosomes and Gene Expression

    DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks

    Shalini Aricthota, Devyani Haldar
    Sirtuin, Hst4 is a novel DDK kinase target, which is modified and degraded in response to replication stress, increasing H3K56 acetylation, to stabilize DNA replication forks via fork protection complex which maintains genome stability and has potential in cancer therapeutics.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a

    Hui Jing, Xiaoyu Zhang ... Hening Lin
    A new post-translational regulatory mechanism of K-Ras is identified, which expands the function of reversible protein lysine fatty acylation and offers new possibility to target the K-Ras oncoprotein.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    The decrotonylase FoSir5 facilitates mitochondrial metabolic state switching in conidial germination of Fusarium oxysporum

    Ning Zhang, Limin Song ... Wenxing Liang
    The decrotonylase FoSir5 modulates ATP synthesis that supports conidial germination in Fusarium oxysporum through coordinated lysine decrotonylation in different organelles.
    1. Biochemistry and Chemical Biology

    Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice

    Fanbiao Meng, Minxian Qian ... Baohua Liu
    SIRT1 deacetylates SIRT6 at K33 to facilitate DNA double-strand breaks-recognition, subsequent expansion and local chromatin remodeling.

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