Cryo-EM structures of human TPC2 channel in the ligand-bound and apo states reveal the structural mechanism of PI(3,5)P2 lipid regulated gating of TPC2.
Olaya Rendueles, Jorge AM de Sousa, Eduardo PC Rocha
The emergence and evolution of different phage-resistance strategies during coevolution between a phage-sensitive strain and a polylysogenic competitor depend on the amount of phage pressure, the fitness costs of resistance, and how these may change at different time scales.
Anthony English, Fleur Uittenbogaard ... Benjamin Bruce Land
Δ9-Tetrahydrocannabinol (THC)-E-gel enables robust preclinical study of voluntary THC consumption in mice, revealing sex-dependent psychotomimetic effects that are valuable for understanding cannabimimetic responses.
Md Rakibul Hasan, Maarit Takatalo ... David PC Rice
RAB23 regulates calvarial bone and suture development both independently through, and by cross-talk between, Hedgehog and fibroblast growth factor signaling.
The small ubiquitin-like modifier system directly regulates components of the chloroplast protein import apparatus, that is, TOC proteins, to control chloroplast biogenesis and plant development.