9,656 results found
    1. Biochemistry and Chemical Biology

    The ribosomal protein Asc1/RACK1 is required for efficient translation of short mRNAs

    Mary K Thompson, Maria F Rojas-Duran ... Wendy V Gilbert
    Asc1/RACK1 promotes the translation of mRNAs associated with the translational closed loop complex, which have short open reading frames and encode proteins required for core metabolic processes.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    mRNA-programmed translation pauses in the targeting of E. coli membrane proteins

    Nir Fluman, Sivan Navon ... Yitzhak Pilpel
    Translation pauses occur in strategic positions to facilitate the production of properly folded membrane proteins in bacteria.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition

    Michael Zavortink, Lauren N Rutt ... Olivia S Rissland
    In fruit flies, maternally deposited RNA-binding proteins are removed during the maternal-to-zygotic transition via a mechanism of translational upregulation of Kondo, the key E2 enzyme, at egg activation.
    1. Cell Biology
    2. Computational and Systems Biology

    Regulation of mRNA translation during mitosis

    Marvin E Tanenbaum, Noam Stern-Ginossar ... Ronald D Vale
    Ribosomal profiling reveals that translational repression is an important mechanism for cell cycle control and can complement protein degradation.
    1. Chromosomes and Gene Expression

    Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology

    Markus Terrey, Scott I Adamson ... Susan L Ackerman
    Disruption of quality control pathways that function at distinct steps to mitigate errors in translation evoke similar cellular responses and pathologies.
    1. Microbiology and Infectious Disease

    Genome-wide regulatory dynamics of translation in the Plasmodium falciparum asexual blood stages

    Florence Caro, Vida Ahyong ... Joseph L DeRisi
    Ribosome profiling has bridged the knowledge gap between transcription and translation during malaria blood stage development and provided a comprehensive gene expression resource for this parasite.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The translational landscape of the splicing factor SRSF1 and its role in mitosis

    Magdalena M Maslon, Sara R Heras ... Javier F Cáceres
    Identifying the translational targets of the shuttling protein, SRSF1, reveals that it is needed for normal cell division, and suggests that it couples pre-mRNA splicing and translation.
    1. Neuroscience

    Coding strategies in the otolith system differ for translational head motion vs. static orientation relative to gravity

    Mohsen Jamali, Jerome Carriot ... Kathleen E Cullen
    Through different coding strategies, irregular and regular otolith afferents preferentially encode translational self-motion and changes in static head orientation relative to gravity.
    1. Chromosomes and Gene Expression

    Ribosome recycling is not critical for translational coupling in Escherichia coli

    Kazuki Saito, Rachel Green, Allen R Buskirk
    Without ribosome recycling factor, ribosomes in Escherichia coli accumulate in 3'-UTRs and queue upstream of stop codons, but no effects were observed on the translational coupling of neighboring genes.
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells

    Jacob W Freimer, TJ Hu, Robert Blelloch
    The deletion of Ddx6 results in the translational upregulation, but not transcript stabilization, of microRNA targets in embryonic stem cells while largely phenocopying the overall impact of global microRNA loss.

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