Browse our latest Chromosomes and Gene Expression articles

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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Vascular Endothelium: More than just a simple barrier

    Erandi Velazquez-Miranda, Ming He
    Endothelial cell subpopulations are characterized by unique gene expression profiles, epigenetic landscapes and functional properties.
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    1. Cell Biology
    2. Chromosomes and Gene Expression

    Imaging analysis of six human histone H1 variants reveals universal enrichment of H1.2, H1.3, and H1.5 at the nuclear periphery and nucleolar H1X presence

    Monica Salinas-Pena, Elena Rebollo, Albert Jordan
    Imaging analysis confirms ChIP-Seq data on the distinct genomic distribution of histone H1 variants in AT-rich, nuclear peripheral regions (H1.2, H1.3, H1.5, H1.0) or GC-rich, throughout the nucleus (H1.4, H1X).
    1. Chromosomes and Gene Expression

    Epigenetics: Linking environmental factors and gene regulation

    Signe Penner-Goeke, Elisabeth B Binder
    A technique called mSTARR-seq sheds light on how DNA methylation may shape responses to external stimuli by altering the activity of sequences that control gene expression.
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    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Dynamic 1D search and processive nucleosome translocations by RSC and ISW2 chromatin remodelers

    Jee Min Kim, Claudia C Carcamo ... Carl Wu
    Single-particle imaging of RSC and ISW2 chromatin remodelers on DNA stretched between dual optical tweezers reveals distinctive 1D diffusion and opposing push–pull nucleosome translocation on engagement with sparse nucleosome arrays.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Chromatin Remodeling: The voyage is as important as the harbor

    Anton Sabantsev, Sebastian Deindl
    To find nucleosomes, chromatin remodelers slide and hop along DNA, and their direction of approach affects the direction that nucleosomes slide in.
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    1. Chromosomes and Gene Expression
    2. Neuroscience

    Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory

    Claire C Chen, Joseph Han ... Andrej Luptak
    The mammalian CPEB3 self-cleaving ribozyme modulates expression of the CPEB3 mRNA and protein, altering translation of plasticity-related proteins and hippocampus-dependent memory.