Orbitofrontal neurons acquire responses to 'valueless' Pavlovian cues during unblocking
- National Institute on Drug Abuse, United States
- University of Pittsburg, United States
- University of Maryland School of Medicine, United States
- National Taiwan University, Taiwan
- Johns Hopkins University, United States
Abstract
The orbitofrontal cortex (OFC) has been described as signaling outcome expectancies or value. Evidence for the latter comes from the studies showing that neural signals in the OFC correlate with value across features. Yet features can co-vary with value, and individual units may participate in multiple ensembles coding different features. Here we used unblocking to test whether OFC neurons would respond to a predictive cue signaling a 'valueless' change in outcome flavor. Neurons were recorded as the rats learned about cues that signaled either an increase in reward number or a valueless change in flavor. We found that OFC neurons acquired responses to both predictive cues. This activity exceeded that exhibited to a 'blocked' cue and was correlated with activity to the actual outcome. These results show that OFC neurons fire to cues with no value independent of what can be inferred through features of the predicted outcome.
Article and author information
Author details
Reviewing Editor
- Howard Eichenbaum, Boston University, United States
Ethics
Animal experimentation: Rats were tested at the University of Maryland School of Medicine and the NIDA-IRP in accordance with SOM and NIH guidelines (12-CNRB-108).
Version history
- Received: February 26, 2014
- Accepted: July 17, 2014
- Accepted Manuscript published: July 18, 2014 (version 1)
- Accepted Manuscript updated: July 20, 2014 (version 2)
- Version of Record published: August 14, 2014 (version 3)
Copyright
This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
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Orbitofrontal neurons acquire responses to 'valueless' Pavlovian cues during unblocking
eLife 3:e02653.
https://doi.org/10.7554/eLife.02653
Further reading
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- Biochemistry and Chemical Biology
- Neuroscience
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