A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity
- Hebrew University of Jerusalem, Israel
- Ecole Normale Supérieure, France
Abstract
The cerebellum, a crucial center for motor coordination, is composed of a cortex and several nuclei. The main mode of interaction between these two parts is considered to be formed by the inhibitory control of the nuclei by cortical Purkinje neurons. We now amend this view by showing that inhibitory GABA-glycinergic neurons of the cerebellar nuclei project profusely into the cerebellar cortex, where they make synaptic contacts on a GABAergic subpopulation of cerebellar Golgi cells. These spontaneously firing Golgi cells are inhibited by optogenetic activation of the inhibitory nucleo-cortical fibers both in vitro and in vivo. Our data suggest that the cerebellar nuclei may contribute to the functional recruitment of the cerebellar cortex by decreasing Golgi cell inhibition onto granule cells.
Article and author information
Author details
Reviewing Editor
- Michael Häusser, University College London, United Kingdom
Ethics
Animal experimentation: All animal manipulations were made in strict accordance with guidelines of the Centre National de la Recherche Scientifique and the Hebrew University's Animal Care and Use Committee (Ethic permission # NS-12-12505-4).
Version history
- Received: December 27, 2014
- Accepted: May 11, 2015
- Accepted Manuscript published: May 12, 2015 (version 1)
- Version of Record published: June 10, 2015 (version 2)
Copyright
© 2015, Ankri et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity
eLife 4:e06262.
https://doi.org/10.7554/eLife.06262
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