Complementary control of sensory adaptation by two types of cortical interneurons
- University of Pennsylvania, United States
Abstract
Reliably detecting unexpected sounds is important for environmental awareness and survival. By selectively reducing responses to frequently, but not rarely, occurring sounds, auditory cortical neurons are thought to enhance the brain's ability to detect unexpected events through stimulus-specific adaptation (SSA). The majority of neurons in the primary auditory cortex exhibit SSA, yet little is known about the underlying cortical circuits. We found that two types of cortical interneurons differentially amplify SSA in putative excitatory neurons. Parvalbumin-positive interneurons (PVs) amplify SSA by providing non-specific inhibition: optogenetic suppression of PVs led to an equal increase in responses to frequent and rare tones. In contrast, somatostatin-positive interneurons (SOMs) selectively reduce excitatory responses to frequent tones: suppression of SOMs led to an increase in responses to frequent, but not to rare tones. A mutually coupled excitatory-inhibitory network model accounts for distinct mechanisms by which cortical inhibitory neurons enhance the brain's sensitivity to unexpected sounds.
Article and author information
Author details
Reviewing Editor
- Andrew J King, University of Oxford, United Kingdom
Ethics
Animal experimentation: All experimental procedures are in accordance with NIH guidelines and approved by the IACUC at University of Pennsylvania (protocol number 803266).
Version history
- Received: July 5, 2015
- Accepted: October 1, 2015
- Accepted Manuscript published: October 13, 2015 (version 1)
- Accepted Manuscript updated: October 16, 2015 (version 2)
- Version of Record published: November 11, 2015 (version 3)
Copyright
© 2015, Natan et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Complementary control of sensory adaptation by two types of cortical interneurons
eLife 4:e09868.
https://doi.org/10.7554/eLife.09868
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