Pivotal role for skin trans-endothelial radio-resistant anti-inflammatory macrophages in tissue repair
- Harvard Medical School, United States
- Centro Nacional de Investigaciones Cardiovasculares, Spain
- Max Planck Institute of Molecular Biomedicine, Germany
Abstract
Heterogeneity and functional specialization among skin-resident macrophages are incompletely understood. In this study, we describe a novel subset of murine dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-state and capture blood-borne macromolecules. Unlike other skin-resident macrophages that are reconstituted by bone marrow-derived progenitors after a genotoxic insult, these cells are replenished by an extramedullary radio-resistant and UV-sensitive Bmi1+ progenitor. Furthermore, they possess a distinctive anti-inflammatory transcriptional profile, which cannot be polarized under inflammatory conditions, and are involved in repair and remodeling functions for which other skin-resident macrophages appear dispensable. Based on all their properties, we define these macrophages as Skin Transendothelial Radio-resistant Anti-inflammatory Macrophages (STREAM) and postulate that their preservation is important for skin homeostasis.
Article and author information
Author details
Reviewing Editor
- Satyajit Rath, National Institute of Immunology, India
Ethics
Animal experimentation: Animal studies were approved by the local ethics committee and by the Division of Animal Protection of Comunidad de Madrid (approved protocols PROEX 159/15 and 160/15). All animal procedures conformed to EU Directive 2010/63EU and Recommendation 2007/526/EC regarding the protection of animals used for experimental and other scientific purposes, enforced in Spanish law under Real Decreto 1201/2005
Version history
- Received: February 16, 2016
- Accepted: June 13, 2016
- Accepted Manuscript published: June 15, 2016 (version 1)
- Accepted Manuscript updated: June 17, 2016 (version 2)
- Version of Record published: July 26, 2016 (version 3)
Copyright
© 2016, Barreiro et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
Metrics
-
- 4,306
- views
-
- 768
- downloads
-
- 35
- citations
Views, downloads and citations are aggregated across all versions of this paper published by eLife.
Download links
A two-part list of links to download the article, or parts of the article, in various formats.
Downloads (link to download the article as PDF)
Open citations (links to open the citations from this article in various online reference manager services)
Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)
Pivotal role for skin trans-endothelial radio-resistant anti-inflammatory macrophages in tissue repair
eLife 5:e15251.
https://doi.org/10.7554/eLife.15251
