Decision and navigation in mouse parietal cortex
Abstract
Posterior parietal cortex (PPC) has been implicated in navigation, in the control of movement, and in visually-guided decisions. To relate these views, we measured activity in PPC while mice performed a virtual navigation task driven by visual decisions. PPC neurons were selective for specific combinations of the animal's spatial position and heading angle. This selectivity closely predicted both the activity of individual PPC neurons, and the arrangement of their collective firing patterns in choice-selective sequences. These sequences reflected PPC encoding of the animal's navigation trajectory. Using decision as a predictor instead of heading yielded worse fits, and using it in addition to heading only slightly improved the fits. Alternative models based on visual or motor variables were inferior. We conclude that when mice use vision to choose their trajectories, a large fraction of parietal cortex activity can be predicted from simple attributes such as spatial position and heading.
Data availability
Behavioral and two-photon imaging data have been deposited in Dryad Digital Repository and are available at doi: 10.5061/dryad.ht3564h.
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Data from: Decision and navigation in mouse parietal cortexDryad Digital Repository, doi:10.5061/dryad.j1fd7.
Article and author information
Author details
Funding
Wellcome (109004)
- Julie J Lee
H2020 European Research Council (CORTEX)
- Matteo Carandini
Simons Foundation (325512)
- Kenneth D Harris
- Matteo Carandini
Wellcome (95668)
- Kenneth D Harris
- Matteo Carandini
Wellcome (95669)
- Kenneth D Harris
- Matteo Carandini
Wellcome (205093)
- Kenneth D Harris
- Matteo Carandini
Wellcome (108726)
- Kenneth D Harris
- Matteo Carandini
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Joshua I Gold, University of Pennsylvania, United States
Ethics
Animal experimentation: All experimental procedures were conducted according to the UK Animals Scientific Procedures Act (1986). Experiments were performed at University College London, under a Project Licence (70/8021) released by the Home Office following appropriate ethics review.
Version history
- Received: October 4, 2018
- Accepted: November 16, 2018
- Accepted Manuscript published: November 23, 2018 (version 1)
- Version of Record published: December 19, 2018 (version 2)
Copyright
© 2018, Krumin et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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