2,363 results found
    1. Developmental Biology

    Cardiac neural crest contributes to cardiomyocytes in amniotes and heart regeneration in zebrafish

    Weiyi Tang, Megan L Martik ... Marianne E Bronner
    Lineage analysis reveals that cardiac neural crest contributes to cardiomyocytes across vertebrates and consistent with this, the neural crest gene regulatory program is reactivated upon heart regeneration in zebrafish.
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    1. Developmental Biology

    RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification

    Erica J Hutchins, Shashank Gandhi ... Marianne E Bronner
    The RNA-binding protein Elavl1 directly binds to and stabilizes a single gene product—Draxin mRNA—to prevent premature delamination and maintain specification in cranial neural crest.
    1. Developmental Biology
    2. Medicine

    CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations

    Hironobu Okuno, Francois Renault Mihara ... Hideyuki Okano
    Neural crest cells differentiated from patient-derived cells with mutations in the chromatin remodeler CHD7 show defective delamination, migration and motility in vitro, and defective migration in chick embryos.
    1. Developmental Biology

    Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate

    Dasan Mary Cibi, Masum M Mia ... Manvendra K Singh
    The identification of the splicing code and all the required components of alternative splicing will be crucial for a comprehensive understanding of this process in the neural crest cell biology.
    1. Developmental Biology

    An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution

    Aubrey GA Howard IV, Phillip A Baker ... Rosa A Uribe
    Single-cell dissection of recent neural crest derivatives in the vertebrate zebrafish reveals diverse transcriptomic signatures among differentiating posterior cell types during the embryonic to larval stage transition.
    1. Developmental Biology

    NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress

    Dandan Han, Lars Schomacher ... Christof Niehrs
    NEIL DNA glycosylases are required to counteract oxidative base damages within the mitochondrial genome to safeguard neural crest cell differentiation.
    1. Developmental Biology

    Single-cell profiling coupled with lineage analysis reveals vagal and sacral neural crest contributions to the developing enteric nervous system

    Jessica Jacobs-Li, Weiyi Tang ... Marianne E Bronner
    Single-cell transcriptome analysis of sacral compared with vagal neural crest-derived cells in the developing chick enteric nervous system reveals both similarities and differences between these two cell populations.
    1. Developmental Biology

    A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development

    Christie Ciarlo, Charles K Kaufman ... Leonard I Zon
    Akt activation is required for neural crest differentiation through regulation of Sox10 activity.
    1. Developmental Biology

    Single-cell RNA analysis identifies pre-migratory neural crest cells expressing markers of differentiated derivatives

    Ezra Lencer, Rytis Prekeris, Kristin Bruk Artinger
    Pre-migratory and early migratory neural crest cells in zebrafish are transcriptionally diverse, with some cells expressing genes associated with differentiated derivatives while still in the neural tube.
    1. Developmental Biology

    Single-cell atlas of early chick development reveals gradual segregation of neural crest lineage from the neural plate border during neurulation

    Ruth M Williams, Martyna Lukoseviciute ... Marianne E Bronner
    A single-cell transcriptomic resource of the early chick epiblast from mid-gastrulation through neurulation highlighting emergence of the neural plate border territory, with emphasis on neural crest specification.

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