Lineage analysis reveals that cardiac neural crest contributes to cardiomyocytes across vertebrates and consistent with this, the neural crest gene regulatory program is reactivated upon heart regeneration in zebrafish.
Erica J Hutchins, Shashank Gandhi ... Marianne E Bronner
The RNA-binding protein Elavl1 directly binds to and stabilizes a single gene product—Draxin mRNA—to prevent premature delamination and maintain specification in cranial neural crest.
Hironobu Okuno, Francois Renault Mihara ... Hideyuki Okano
Neural crest cells differentiated from patient-derived cells with mutations in the chromatin remodeler CHD7 show defective delamination, migration and motility in vitro, and defective migration in chick embryos.
Dasan Mary Cibi, Masum M Mia ... Manvendra K Singh
The identification of the splicing code and all the required components of alternative splicing will be crucial for a comprehensive understanding of this process in the neural crest cell biology.
Aubrey GA Howard IV, Phillip A Baker ... Rosa A Uribe
Single-cell dissection of recent neural crest derivatives in the vertebrate zebrafish reveals diverse transcriptomic signatures among differentiating posterior cell types during the embryonic to larval stage transition.
NEIL DNA glycosylases are required to counteract oxidative base damages within the mitochondrial genome to safeguard neural crest cell differentiation.
Jessica Jacobs-Li, Weiyi Tang ... Marianne E Bronner
Single-cell transcriptome analysis of sacral compared with vagal neural crest-derived cells in the developing chick enteric nervous system reveals both similarities and differences between these two cell populations.
Ezra Lencer, Rytis Prekeris, Kristin Bruk Artinger
Pre-migratory and early migratory neural crest cells in zebrafish are transcriptionally diverse, with some cells expressing genes associated with differentiated derivatives while still in the neural tube.
Ruth M Williams, Martyna Lukoseviciute ... Marianne E Bronner
A single-cell transcriptomic resource of the early chick epiblast from mid-gastrulation through neurulation highlighting emergence of the neural plate border territory, with emphasis on neural crest specification.